Other

Leland Stanford Junior University

Tokyo Institute of Technology

Lucy Shapiro

Stephen J Benkovic

Craig P Stephens

Anthony J Berdis

Masaaki Wachi

Irene H Lee

Zemer Gitai

Noritaka Iwai

Rachel Wright

Lyn Sue Kahng

The identification of MreB as essential for bacterial chromosome segregation provides a new target for antibiotic action. The MreB function is useful in the development of screening assays for new antibiotics, which may use, for example, genetic mutants in MreB, tests of MreB mediated chromosome segregation, and the like. In one embodiment of the invention, the antibiotic is an isothiourea compound, which may comprise a polyhalogenated benzyl group, e.g. at the 4 position, the 2,4 position, etc. A pharmaceutical composition comprising an MreB targeted antibiotic as an active agent is administered to a patient suffering from a microbial infection, particularly bacterial infections.

Antibiotics targeting MreB

The present invention relates to the isolation and sequencing of a novel class of methyltransferase genes, including the methyltransferase gene from and The invention further comprises efficient methods of assaying methyltransferase activity.

DNA adenine methyltransferases and uses thereof

Growing community of inventors

Stanford, CA, United States of America

Lucy Shapiro