The Dupont Merck Pharmaceutical Company

Other

E.i. Dupont De Nemours and Company

Merck + Co., Inc.

Dupont Pharmaceuticals Company

Dupont Pharmaceuticals, Inc.

Lucius Thomas Rossano

Young S Lo

Robert D Larsen

Philip Ma

Anthony O King

Jaan A Pesti

Jianguo Yin

Michael B Maurin

Goss S Kauffman

Lin Hua Zhang

Randall K Ward

David John Meloni

The potent platelet glycoprotein IIb/IIIa antagonist, roxifiban, is produced in crystalline form. Crystalline roxifiban exists in two polymorphic forms, designated Form 1 and Form 2. These polymorphic forms are characterized by x-ray powder diffraction and solid-state carbon NMR. Pharmaceutical compositions and methods for the treatment or prevention of diseases mediated by platelet aggregation are described.

Crystalline roxifiban

This invention relates to novel compounds and derivatives thereof containing a trioxepane protected diol in addition to a hydrazone, hydrazine, amine, or cyclic urea moiety; methods for the preparation of said compounds; and the use of said compounds in processes to prepare human immunodeficiency virus (HIV) protease inhibitors which effectively inhibit HIV. The novel compounds provided by this invention have the formulae: ##STR1## wherein the substituents are as defined herein.

Processes and intermediates for the preparation of cyclic urea HIV

Intermediates for the preparation of cyclic urea

Method for the preparing biphenyltetrazole compounds which are angiotensin II receptor antagonists or which are useful intermediates to prepare angiotensin II receptor antagonists. An illustrative biphenyl tetrazole compound is 2-n-butyl-4-chloro-1-[(2'-(tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-im idazole-5-methanol, potassium salt.

Process for preparing biphenyltetrazole compounds

Novel tetrazolylphenylboronic acids, methods for their preparation, and their use in the syntheses of angiotensin II receptor antagonists are disclosed.

Tetrazolylphenylboronic acid intermediates for the synthesis of AII

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Newark, DE, United States of America

Lucius Thomas Rossano