Gen-probe, Inc.

Genewave

Genewave Sas

Lucio Martinelli

Henri Benisty

Claude Weisbuch

Thierry Gacoin

Gabriel Sagarzazu

Mélanie Bedu

Christof Schafauer

Yann Marcy

A biochip device comprising a substrate constituted by at least one plate of material forming a multimode planar waveguide and carrying chromophore elements suitable for emitting fluorescence in response to excitation by guided waves having an evanescent portion, the device being characterized in that it includes coupling means for coupling excitation light with the waveguide in the form of guided waves, the coupling means being substantially non-directional.

Biochip method

A biochip device includes a waveguide, chromophore elements, a diffusing structure, and a sloping surface. The chromophore elements are disposed on a portion of the waveguide and are configured to emit fluorescence in response to excitation by guided light waves transmitted by the waveguide. The diffusing structure is configured to generate guided light waves in the waveguide when illuminated. The sloping surface is sloped relative to a plane of the waveguide and is configured to direct excitation light into the waveguide, and the sloping surface and the waveguide are configured to deflect the excitation light to the diffusing structure to generate guided light waves within the waveguide. The sloping surface may be a face of a prism attached to or integrated with the waveguide, or the sloping surface may be a bevel formed at an edge of the waveguide.

Biochip device

An imaging method and a device for detecting the fluorescence of a biochip by illuminating chromophores associated with probes () of a substrate () placed on a sensor () having photodetectors, e.g. of the CCD or CMOS type, a stop filter that rejects the excitation light of the chromophores being provided between the probes () and the sensor, the substrate () being separable from the sensor () after use so as to enable the sensor to be reused.

Method and a device for detecting the fluorescence of a biochip

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Paris, France

Lucio Martinelli