Universiteit Antwerpen

Lucien Nagels

Karolien De Wael

Freddy Dardenne

Guido F E Van Camp

Ronny J P Blust

Guido Van Camp

Ronny JP Blust

Guido FE Van Camp

This invention provides:&#x2014;an aptamer-based electrochemical sensor, wherein said aptamer is covalently bonded to or chemisorbed on an electrode, said aptamer forming a complex with a target molecule and is encapsulated by a gelatin B matrix;&#x2014;a method of manufacturing said aptamer-based electrochemical sensor;&#x2014;the use of the aptamer-based electrochemical sensor for the electrochemical determination of a concentration of a target molecule; and&#x2014;a composite electrode combining a polymeric material and electrically conducting particles for selective analyte detection, wherein said electrode is coated with gelatin type B.

Electrochemical aptasensors with a gelatin B matrix

This invention provides: &#x2014;an aptamer-based electrochemical sensor, wherein said aptamer is covalently bonded to or chemisorbed on an electrode, said aptamer forming a complex with a target molecule and is encapsulated by a gelatin B matrix; &#x2014;a method of manufacturing said aptamer-based electrochemical sensor; &#x2014;the use of the aptamer-based electrochemical sensor for the electrochemical determination of a concentration of a target molecule; and &#x2014;a composite electrode combining a polymeric material and electrically conducting particles for selective analyte detection, wherein said electrode is coated with gelatin type B.

A coated-wire potentiometric sensor comprising an electronically conducting substrate electrode coated with an ionically conductive sensing layer and an outermost surface consisting of or comprising in and/or on a first molecular species which is capable of reversibly adsorbing a second molecular species and a method for measuring the affinity between a first molecular species and a second molecular species comprising the steps of: providing a potentiometric sensor of the coated-wire type having an outermost surface; adapting said outermost surface so that consists of or comprises said first molecular species; placing said sensor in a system for the recording of sensorgrams; recording a sensorgram of the adsorption of a second molecular species on said first molecular species of or comprised in and/or on said adapted outermost surface.

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Heffen, Belgium

Lucien Nagels