L'oreal

Loreal Sa

Xl'oreal

Lucie Simonetti

Maria Dalko

Jean-Baptiste Galey

Dominique Bernard

Jean-Luc M Leveque

Christophe Boulle

Isabelle Castiel

Bruno Mehul

Pascale Pelletier

Mark Donovan

The invention relates to the use of one or more complexed or noncomplexed, soluble peptide form(s) of Desmoglein I, as a marker for evaluating the effectiveness of active agents and/or of treatments, in particular anti-ageing active agents and/or treatments, with regard to an epidermis.

Use of soluble forms of the Desmoglein I protein for the purposes of screening for anti-ageing active agents

The present invention relates to the use, especially the cosmetic and/or therapeutic use, of the protein DJ-1, of polypeptides derived from this protein or of analogs thereof, of a nucleic acid sequence coding for such a polypeptide or of a modulator of the activity, stability or expression of such a polypeptide, especially for preventing and/or treating the signs of skin dryness. The invention also relates to the use of the protein DJ-1, of polypeptides derived from this protein or of analogs thereof or of a nucleic acid sequence coding for such a polypeptide, as a marker for evaluating the state of dryness of an epithelium.

Cosmetic and therapeutic use of proteins of DJ-1 type for treating skin dryness

The subject of the present invention is the use, in particular the cosmetic and/or therapeutic use, of the apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, of a nucleic sequence encoding such a polypeptide or of an agent modulating the activity or of the expression of such a polypeptide, in particular for stimulating terminal epithelial differentiation. The invention also relates to the use of the protein apolipoprotein D, of polypeptides derived from this protein or of analogues thereof, or of a nucleic sequence encoding such a polypeptide as a marker for evaluating the state of the epidermis.

Cosmetic use of apolipoprotein D type proteins

Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein:

Compositions comprising jasmonic acid derivatives and use of the derivatives

Compositions comprising jasmonic acid derivatives and use of these derivatives

Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein: Ris a radical chosen from &#x2014;COOR', &#x2014;CONR&#x2032;R&#x2033;, &#x2014;CHOR&#x2032;, &#x2014;COR&#x2032;, &#x2014;CHR&#x2032;, &#x2014;SOOR&#x2032;, &#x2014;POR&#x2032;R&#x2033; and &#x2014;NHR&#x2032;, wherein R&#x2032; and R&#x2033;, which may be identical or different, are defined herein; Ris chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from &#x2014;OR&#x2032;&#x2033;, &#x2014;OCOR&#x2032;&#x2033;, &#x2014;SCOR&#x2032;&#x2033;, NR&#x2032;&#x2033;R&#x2033;&#x2033;, &#x2014;NHCOR&#x2032;&#x2033;, halogen, &#x2014;CN, &#x2014;COOR&#x2032;&#x2033; and &#x2014;COR&#x2032;&#x2033;, wherein R&#x2032;&#x2033; and R&#x2033;&#x2033;, which may be identical or different, are defined herein; as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.

Signs of aging of the skin and/or mucous membranes are prevented and/or reduced, and the activity of the proteolytic enzymes of the stratum corneum are stimulated as well, by administering to an individual in need of such treatment, a cosmetic/pharmaceutical composition which comprises a thus effective amount of at least one hydroxylated urea compound having the following formula (I): in which: the radicals R1, R2, R3 and R4, which may be identical or different, are each a hydrogen atom, a C-Calkyl radical or a C-Chydroxyalkyl radical which can contain from 1 to 5 hydroxyl groups, wherein at least one of the R1 to R4 radicals represents a hydroxyalkyl radical, or salt, solvate or isomer thereof, formulated into a physiologically acceptable medium therefor.

Administration of urea compounds for combating signs of cutaneous aging

The invention relates to the use of at least one urea derivative of the following formula (I) in a composition containing a physiologically acceptable medium, as agent intended for stimulating desquamation of the skin and/or the mucous membranes. It also relates to a method of cosmetic treatment and cosmetic agents containing it.

Urea compounds that promote desquamation

The invention concerns an isolated polypeptide, of the family of calcium-fixing proteins, a mixture of polypeptides derived from proteolysis of the isolated polypeptide, compositions containing them, the uses of said polypeptide and a cosmetic treatment method for dry skin, hyperkeratosis, parakeratosis, psoriasis, ichthyosis, and neoplasia. The invention also concerns a deoxyribonucleic acid sequence coding for said polypeptide and the uses of said deoxyribonucleic sequence.

Isolated polypeptide of the stratum corneum and its use

The invention concerns an isolated polypeptide, of the family of calcium-fixing proteins, a mixture of polypeptides derived from proteolysis of the isolated polypeptide, compositions containing them, the uses of said polypeptide and a cosmetic treatment method for dry skin, hyperkeratosis, parakeratosis, psoriasis, ichthyosis, neoplasia. The invention also concerns a deoxyribonucleic acid sequence coding for said polypeptide and the uses of said deoxyribonucleic sequence.

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Vincennes, France

Lucie Simonetti