Dsm IP Assets B.v.

Lucie Parenicova

Jan Metske Van Der Laan

Noël Nicolaas Maria Elisabeth Van Peij

Ronald Busink

Alrik Pieter Los

Johannes Andries Roubos

Liang Wu

Herman Jan Pel

Noel Nicolaas Maria Elisabeth Van Peij

Jan Metske Van Der Lann

Jan Metske Laan Van Der

Jan Herman Pel

Noël Nicolaas Maria Elisabeth Peij Van

Van Der Jan Metske Laan

Van Noël Nicolaas Maria Elisabeth Peij

The present invention relates to novel lipase polynucleotide sequences, their corresponding proteins as well as ways of manufacturing said sequences and said proteins and use of the proteins in the preparation of food compositions. The invention further relates to methods for releasing proteins from the exterior of a host cell as well as to a method for killing micro-organisms.

Pregastric esterase and derivatives thereof

The present invention relates to a method for improving protein yield. The method comprises modifying the value of a set of relevant protein features to fall within an optimal range or to become more close to an optimal value for one or more protein features in the eukaryotic host.

Method for improving the yield of a polypeptide

The present invention relates to functional cDNA and genomic sequences encoding PrtT proteins, which are transcriptional activity on a protease promoter, to PrtT proteins and their uses. The invention further relates to two distinct types of filamentous fungal cells. Filamentous fungal cells are transformed to over-express these PrtT proteins: this type of filamentous fungus will be highly suited as protease producer. Alternatively, the endogenous prtT genes of filamentous fungal cells are inactivated: this type of filamentious fungus is highly suited for the production of any polypeptide native or not which is highly sensitive for protease degradation. The PrtT proteins of the invention provide means for identification of functional homologues in other species.

Fungal transcriptional activators useful in methods for producing a polypeptide

This invention relates to an alpha-amylase, a process for its preparation and the use of the amylase. The invention relates to a newly identified polynucleotide sequence fromcomprising a gene that encodes the alpha-amylase enzyme. The invention features the full-length coding sequence of the gene as well as the amino acid sequence of the full-length functional protein of the gene. The invention also relates to methods of using these proteins in industrial processes, for example in food industry, such as the baking industry. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins and cells.

Alpha-amylase

The present invention relates to functional cDNA and genomic sequences encoding PrtT proteins, which have transcriptional activity on a protease promoter, to PrtT proteins and to their use. The invention further relates to two distinct types of filamentous fungal cells. Filamentous fungal cells are transformed to over-express these PrtT proteins: this type of filamentous fungus will be highly suited as protease producer. Alternatively, the endogenous prtT genes of filamentous fungal cells are inactivated: this type of filamentous fungus is highly suited for the production of any polypeptide native or not which is highly sensitive for protease degradation. The PrtT proteins of the invention provide means for identification of functional homologues in other species.

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Echt, Netherlands

Lucie Parenicova