Mikrobiologyicky Ustav Ag Cr, V. V. I.

Mikrobiologicky Ustav Av Cr, V.v.i.

Lucie Najmanova

Radek Gazak

Zdenek Kamenik

Jiri Janata

Stanislav Kadlcik

Lincosamides of general formula I, where R1 is selected from C2-C8 alkyl or C2-C8 alkenyl; R3 is selected from OH, O(C1-C4 alkyl), SH, S(C1-C4 alkyl) or halogen; R4 is H or C1-C3 alkyl; each of R21, R22, R23, R24, R25 is independently selected from the group consisting of H, OH, C1-C4 alkyl, C1-C4 alkenyl, C1-C4 alkynyl, halogen, O(C1-C4 alkyl), O(C1-C4 alkenyl), O(C1-C4 alkynyl), NH, N(C1-C4 alkyl), N(C1-C4 alkenyl), N(C1-C4 alkynyl); and pharmaceutically acceptable salts thereof. A method of preparation thereof, in particular a biosynthetic method using newly discovered functions of celesticetin biosynthetic proteins Ccb1 and/or Ccb2. Lincosamides of general formula I are suitable for use as antibacterial and antiprotozoal substances.

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Prague, Czechia

Lucie Najmanova