Bracco Industria Chimica, S.p.a.

Bracco Chimica S.p.a.

Bracco Industria Chemica S.p.a.

Luciano Fumagalli

Fulvio Uggeri

Ernst Felder

Giorgio Vittadini

Carlo Musu

Giorio Vittadini

Ernest Felder

Comounds having the formula ##STR1## wherein: a is 2 or 3; b is an integer from 0 to 4;

Paramagnetic chelates

Macrocyclic derivatives of 1,4,7,10-tetraazacyclododecane of general formula (I) hereinbelow, wherein A is a group of formula (II) hereinbelow, in which R is H or alkyl or optionally substituted benzyl or a H(OCH.sub.2 CH.sub.2).sub.1-4-, Me(OCH.sub.2 CH.sub.2).sub.1-4-, or Et(OCH.sub.2 CH.sub.2).sub.1-4- group, X or O--R.sub.1, in which R.sub.1 is H or alkyl, hydroxyalkyl, alkoxyalkyl, alkoxyhydroxyalkyl or a polyoxaalkyl group or X is --NR.sub.2 R.sub.3, in which R.sub.2 and R.sub.3 are H or alkyl, hydroxyalkyl, alkoxyalkyl or alkoxyhydroxyalkyl, and B.sub.1, B.sub.2 and B.sub.3 have the same meanings as A or are H or a group of formula (III) hereinbelow, in which R.sub.4 is H or alkyl, Y is a O--R.sub.5 group, wherein R.sub.5 is H or alkyl, hydroxyalkyl, alkoxyalkyl, alkoxyhydroxyalkyl or a polyoxaalkyl group, or Y is a --NR.sub.6 R.sub.7 group, wherein R.sub.6 and R.sub.7 are H or alkyl, hydroxyalkyl, alkoxyalkyl, or alkoxyhydroxyalkyl, said derivatives optionally being salified, and the complex salts thereof, are used as pharmaceuticals and/or diagnostic agents. ##STR1##

Macrocyclic chelating agents and chelates thereof

Preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid

Compounds suitable for NMR imaging having the formula: ##STR1## wherein a is 2 or 3;

Paramagnetic chelates useful for NMR imaging

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Milan, Italy

Luciano Fumagalli