Istituto Gentili S.p.a.

Luciano Fontanelli

Sergio Rosini

Dermatological and cosmetic compositions

This invention relates to pharmaceutical compositions for the treatment of arthrosis by intraarticular administration of the compositions diluted in a suitable aqueous or lyophilized carrier, comprising an effective amount of diphosphonates and amino acids, specifically aminocarboxylic acids, added thereto as stabilizers. The invention also relates to a therapeutic method for the treatment of arthrosis by intraarticular administration of the compositions into the body of human beings and animals.

Pharmaceutical compositions based on diphosphonates for the treatment of

A method for the preparation of tablets slowly releasing the active principle, characterized in that (I) during the granulation step a solution in organic solvents of a polymer insoluble in biological juices is sprayed on a mixture containing an active principle, slightly swelling polymers and usual excipients; (II) the granulated obtained in this way is added with a highly hydroswelling colloidal polymer; (III) a solution, in organic solvents, of an entero-soluble polymer, is sprayed on the granulate; (IV) the resulting granulate is submitted to compression; (V) the obtained tablets are hardened by washing with organic solvents; and (VI) they are then optionally coated.

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Pisa, Italy

Luciano Fontanelli