Amazon Technologies, Inc.

Luciano Braggio

William Greger

Aida Martin Galan

Manuela Alanis

Emanuel Elizalde

Ryan Patrick Rafter

Andrea Larsen

Bruno Nicolas Bavaresco Elissetche

Matias Ezequiel Andreoli

Mark Patrick Kreuzer

Diagnostic testing systems and related methods employ actuation pressure-based control during fluid transfer within a test cartridge. A method of operating a cartridge to process a biological sample includes coupling an actuation port of the cartridge with a pump assembly of a portable analyzer. A transfer operation of the pump assembly induces airflow through the actuation port so as to displace an aliquot of the sample solution along a fluid channel. A control unit monitors a pressure signal indicative of a pressure of air displaced by the pump assembly. The transfer operation is stopped in response to a change in the pressure signal indicative of contact of the aliquot of the sample solution with a hydrophobic staging vent.

Microfluidic systems and methods

Single use cartridges for testing biological samples are provided that include multiple processing channels. A single use cartridge includes an aliquot staging well, a first amplification well, a second amplification well, an actuation port, and a fluid channel control valve assembly. The fluid channel control valve assembly is reconfigurable between a first fluid channel configuration and a second fluid channel configuration.

Assay cartridge

Growing community of inventors

Santa Fe, Argentina

Luciano Braggio