Centre National De La Recherche Scientifique

Universitat Basel

Lucia Mori

Gennaro De Libero

Germain Puzo

Martine Gilleron

Jacques Prandi

Samantha Paoletti

Julie Guiard

Marco Lepore

The invention relates to a method of isolating a T cell that expresses a T cell receptor capable of binding specifically to an antigen presented by a cancer cell in association with an MR1 molecule. The method comprises the steps of (a) providing a preparation of T cells, (b) contacting the preparation with cancer cells expressing MR1 protein; (c) isolating a T cell that is specifically reactive to said cancer cells. The invention further relates to a method of preparing a T cell preparation expressing select MR1 recognizing T cell receptors from transgene expression vectors, the use of such T cell preparations in treatment of cancer, and to collections of MR1 reactive T cell receptor encoding nucleic acids and cells.

MR1 restricted T cell receptors for cancer immunotherapy

The present invention relates to compounds of the following general formula (I) their process of preparation and their use in the treatment or the prophylaxis of tuberculosis.

Sulfoglycolipid antigens, their process of preparation, and their use against tuberculosis

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Bale, Switzerland

Lucia Mori