Baxalta Gmbh

Takeda Pharmaceutical Company Limited

Lucia Gnauer

Hans-Peter Schwarz

Wolfgang Teschner

Alfred Weber

Harald Arno Butterweck

Bernhard Koelbl

Theresa Friederike Bauer

Bernhard Kölbl

Gerhard Sekot

Methods are provided for the manufacture of plasma-derived immunoglobulin G compositions highly enriched for anti-parvo B19 immunoglobulin G. The methods provided do not affect the manufacturing processes or capabilities for producing plasma-derived IgG therapeutics. Plasma-derived IgG compositions that are highly enriched for anti-parvo B19 immunoglobulin G are also provided. Methods for treating parvo B19 infections by administration of plasma-derived IgG compositions highly enriched for anti-parvo B19 immunoglobulin G are also provided.

Human plasma-derived IGG preparation enriched in anti-parvo B19 natural IGGS

The present invention provides, among other aspects, methods for the manufacture of plasma-derived immunoglobulin G compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-A&#x3b2;, anti-RAGE, and anti-&#x3b1;-synuclein antibodies). Advantageously, the methods provided do not affect the manufacturing processes or capabilities for producing plasma-derived IgG therapeutics. Plasma-derived IgG compositions that are highly enriched for anti-brain disease related protein antibodies (e.g., anti-A&#x3b2;, anti-RAGE, and anti-&#x3b1;-synuclein antibodies), as also provided here. Methods for the treatment of brain diseases and disorders by administration of plasma-derived IgG compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-A&#x3b2;, anti-RAGE, and anti-&#x3b1;-synuclein antibodies), are also provided.

Methods to produce a human plasma-derived IgG preparation enriched in brain disease-related natural iggs

Methods to produce a human plasma-derived IgG preparation enriched in brain disease-related natural IgGs

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Eggenburg, Austria

Lucia Gnauer