Firmenich Sa

Firemenich Sa

Innovaroma Sa

Lucia Bonomo

Philippe Dupau

Denis Jacoby

Laurent Kermorvan

Serge Bonnaudet

Murielle Haldimann Sanchez

Simone Chappuis

Virginie Blanchard

Described herein is a process for the preparation of a mixture of compounds of formula having a weight ratio of the cis-diastereomers to trans-diastereoisomers higher than 1:1, where Rrepresents a Calkyl group, a Calkenyl group or a Calkynyl group, each optionally substituted with one or two of a Calkyl alkoxy ether group and/or a Calkyl carboxylester group and Rrepresents a Calkyl, a Calkenyl or a Calkynyl group, each optionally substituted with a Calkyl alkoxy ether group, a carboxylic acid group or a Calkyl carboxylester group and compounds suitable in the process.

Process for the preparation of cis-alpha,beta substituted cyclopentanones

The present invention relates to the field of organic synthesis and more specifically it concerns a process for preparing compound of formula (I) catalyzed by a nickel complex. The compound of formula (II) is also part of the invention.

Process for preparing diene

Described herein are catalytic hydrogenation processes, using Ru complexes with tetradentate ligands of formula L in hydrogenation processes for the reduction of ketone, aldehyde, ester, or lactone into the corresponding alcohol or diol respectively. These processes use a ruthenium complex of formula (1) as defined herein.

Hydrogenation of carbonyls with tetradentate PNNP ligand ruthenium complexes

The present invention relates to processes for the reduction by hydrogenation, using molecular H, of a C-Csubstrate containing one or two aldehydes functional groups into the corresponding alcohols or diol, characterized in that said process is carried out in the presence of &#x2014;at least one catalyst or pre-catalyst in the form of a ruthenium complex having a coordination sphere of the NPO, wherein the coordinating atom N and one coordinating atom P are provided by a first bidentate ligand, and the two other coordinating atoms Pare provided by a second bidentate ligand and the coordinating atoms Oare provided by two non-linear carboxylate ligands; and &#x2014;optionally of an acidic additive.

Selective hydrogenation of aldehydes with Ru/bidentate ligands complexes

The present invention relates to processes for the reduction by hydrogenation, using molecular H, of a C-Csubstrate containing one or two aldehydes functional groups into the corresponding alcohol or diol, characterized in that said process is carried out in the presence of &#x2014;at least one catalyst or pre-catalyst in the form of a ruthenium complex having a coordination sphere of the NPO, wherein the coordinating atoms Nare provided by a first bidentate ligand, the coordinating atoms Pare provided by a second bidentate ligand and the coordinating atoms Oare provided by two non-linear carboxylate ligands; and&#x2014;optionally of an acidic additive.

Selective hydrogenation of aldehyde with ru/bidentate ligands complexes

The present invention relates to the field of catalysis and, more particularly, to a ruthenium carbonate complex of formula [Ru(diene)(C0)] or [Ru(diene)(C0)]M, wherein M is an alkaline (n is 2) or alkaline earth (n is 1) cation. The invention relates also to the use of said ruthenium carbonate complex as precursors for a number of Ru carboxylate complexes. Said specific ruthenium complexes possess a number of important advantages over the similar prior art known precursors.

Ruthenium based complexes

The present invention relates to the field of one step process for the preparation of monomeric or dimeric [Ru(diene)(OOCR)]complexes from [(diene)RuCl], as well as a new class of [Ru(diene)(OOCR)]complexes and their use to prepare [Ru(PP)(OOCR)] complexes, which are good catalysts.

The present invention relates to the use of Ruthenium complexes having cyclopentadienyl derivatives and a diene as ligands, together with some acidic additives for improving the selectivity in the 1,4-hydrogenation of conjugated dienes into the corresponding 'cis'-alkene as major product, i.e. wherein the two substituents in position 2,3 of the diene are in a cis configuration in the corresponding alkene.

1,4-hydrogenation of dienes with Ru complexes

The present invention relates to the use of Ru complexes, having a pentamethyl-cyclopentadienyl and a cyclooctadine as ligands, together with some acidic additives for improving the selectivity in the 1,4-hydrogenation of sorbol into the corresponding Z-alkene as major product.

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Geneva, Switzerland

Lucia Bonomo