Societe Civile Bioprojet

Rhone-poulenc Nutrition Animale

Rhone-poulenc Sante

Institut National De La Sante Et De La Recherche Medicale

Rhone-poulenc Chimie

Bioprojet

Societe Civile Bioproject

Other

Lucette Duhamel

Pierre Duhamel

Jean-Charles Schwartz

Jeanne-Marie Lecomte

Denis Danvy

Claude Gros

Jean-Christophe Plaquevent

Thierry Monteil

Jean-Marie Poirier

Jerome Guillemont

Nadine Noel

Pierre F Chabardes

Bruno Giros

Jean-Pierre LeCouve

Olivier Chamard

Serge Piettre

Bertrand Leblond

Helene Greciet

Pierre F Charbardes

Christophe Lusson

Jean-Erick Ancel

Bienayme, Hugues

Nadine Noel-Lefebvre

The invention relates to compounds which constitute a class of medicaments which have an anti-inflammatory activity and which act by inhibiting leukotriene A(LTA), and enzyme which is responsible for the biosynthesis of leukotriene LTB, a major proinflammatory mediator. The invention also relates to therapeutic anti-inflammatory, applications of these compounds as well as for methods of preparing these compounds.

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The invention concerns compounds inhibiting LTAhydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications.

LTA4 hydrolase inhibitors

Process for synthesizing N-(mercaptoacyl) amino acid derivatives from alpha-substituted acrylic acids

The invention concerns LTA hydrolase inhibiting compositions of formula (1) as set forth below. It also concerns their therapeutic, in particular anti-inflammatory, applications.

Process for the asymmetric synthesis of S-acyl derivatives of

Process for the synthesis of .alpha.-substituted acrylic acids of general formula (I) and their application to the synthesis of N-(mercaptoacyl)aminoacid derivatives of formula (II). ##STR1##

Process for the synthesis of .alpha.-substituted acrylic acids and their

The present invention relates to new fluorinated hexane compounds corresponding to the following general formula (II): ##STR1## in which X'.sub.2, X'.sub.3, and X'.sub.4 are the same or different, and denote a halogen or a pseudohalogen, preferably a halogen, more preferably chlorine and fluorine, with the condition that, when R.sub.1 is hydroxyl, cyano, amido, imido, ethoxy, benzyloxy, cyclohexyloxy and tert-butoxy, not all the halogens can simultaneously be chlorine and R.sub.4, R.sub.3 and R.sub.5 are simultaneously equal to H;

Process for preparation of halogenated or pseudohalogenated cyclic

Process for the synthesis of a-substituted acrylic acids and their application. Process for the synthesis of a-substituted acrylic acids of general formula (I) and their application to the synthesis of N- (mercaptoacyl) aminoacid derivatives of formula (II). ##STR1##

Amino acid derivatives having both enkephalinase and ACE inhibiting properties corresponding to the formula: ##STR1##

Amino acid derivatives, the process for their preparation and their

New amino acid derivatives, processes for their preparation, and their therapeutic application are described. These amino acid derivatives correspond to the general formulae ##STR1## These derivatives may be used as medicaments which exhibit an enkephalinase-inhibitory activity.

Amino acid derivatives, processes for their preparation and their

New amino acid derivatives, processes for their preparation and their therapeutic application. Amino acid derivatives corresponding to the general formulae ##STR1## These derivatives may be used as medicaments which exhibit an enkephalinase-inhibitory activity.

Amino acid, derivatives, processes for their preparation and their

Amino acid derivatives of formula (Ia) and (Ib) and prodrugs thereof containing a group responsible for chelating the zinc atom of enkephalinase and angiotensin convertase enzymes are disclosed as inhibitors of these enzymes.

The present invention relates to a new method of condensing polyenic compounds wherein a compound having the formula III ##STR1## is condensed with a compound having the formula IV ##STR2## under the influence of a Lewis acid or a protic acid. R.sub.1 through R.sub.7 represent alkyl or alkenyl groups, A' is preferably chlorine, B is preferably a hydroxyl group, and n' is 0 to 10. The invention also relates to novel intermediates for use in the preparation of Vitamins A and E produced by means of the new method.

Intermediates for preparing vitamins A and E and carotenoids

The present invention relates to new fluorinated hexane compounds corresponding to the following general formula (II): ##STR1## in which X'.sub.2, X'.sub.3 and X'.sub.4 are the same or different, and denote a halogen or a pseudohalogen, preferably a halogen, more preferably chlorine and fluorine, with the condition that, when R.sub.1 is hydroxyl, cyano, amido, imido, ethoxy, benzyloxy, cyclohexyloxy and tert-butoxy, not all the halogens can simultaneously be chlorine and R.sub.4, R.sub.3 and R.sub.5 are simultaneously equal to H;

Synthesis intermediates containing a hexane ring and processes for their

The (R) or (S) isomer of acetorphan or N-/(acetylthiomethyl)-2-oxo-1-phenyl-3-propyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-3-benzyl-2-propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupling with the corresponding amino acid ester. The obtained preparations possess remarkable therapeutic activities and can notably be used as drugs.

Growing community of inventors

Mont Saint Aignan, France

Lucette Duhamel