Albert Einstein College of Medicine

Stichting Het Nederlands Kanker Instituut-antoni Van Leeuwenhoek Ziekenhuis

Lucas Tilmann Jae

Kartik Chandran

Thijn Reinout Brummelkamp

Matthijs Raaben

Joppe Daniël Maria Nieuwenhuis

Markus Brockmann

Vincent Arthur Blomen

Thijin R Brummelkamp

Rohit K Jangra

Joppe Daniel Nieuwenhuis

The present invention comprises generally applicable methods for identifying endogenous physiologically relevant genetic elements that affects a intracellular phenotype of interest. In the methods, non-living cells that have been subjected to a mutagenesis treatment are sorted based on phenotype and analyzed to identify the genetic element. By use of these methods, elements previously unknown to be involved in a phenotype can be identified, for example in relationship to health conditions, external stress or drug response, in particular in cancer.

Assays to identify genetic elements affecting phenotype

Methods and assays are disclosed for treating a subject with a hantavirus infection using an agent that binds to protocadherin-1 (PCDH1) or inhibits expression of protocadherin-1 (PCDH1).

Methods and assays for treating hantavirus infections

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Amsterdam, Netherlands

Lucas Tilmann Jae