Eureka Therapeutics, Inc.

Lucas Horan

Hong Liu

Yiyang Xu

Zhiyuan Yang

Cheng Liu

Su Yan

Jingwei Lu

Vivien Wai-Fan Chan

Lianxing Liu

Pengbo Zhang

Hongruo Yun

Binnaz K Staley

Javier Morales

Shan Li

Xiaomei Ge

Yixiang Xu

The present application provides constructs comprising an antibody moiety that specifically binds to PSMA (e.g., PSMA expressed on the surface of a cell). Also provided are methods of making and using these constructs.

Constructs targeting prostate-specific membrane antigen (PSMA) and uses thereof

The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

Antibody/T-cell receptor chimeric constructs and uses thereof

The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.

Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof

The present application provides chimeric antibody-TCR constructs comprising an antigen-binding module that specifically binds to a target antigen and a T cell receptor module capable of recruiting at least one TCR-associated signaling molecule. Also provided are methods of making and using these constructs.

Chimeric antibody/T-cell receptor constructs and uses thereof

Growing community of inventors

Emeryville, CA, United States of America

Lucas Horan