The General Hospital Corporation

Massachusetts Institute of Technology

Luca Zazzeron

Warren M Zapol

R Rox Anderson

William A Farinelli

Walfre Franco

Vamsi K Mootha

Richard Rox Anderson

Isha Jain

Anna Fischbach

Rox R Anderson

A system includes an enclosed tent or chamber or a breathing apparatus, a hypoxia induction system and a device for measuring arterial oxygen saturation in a subject breathing air within the enclosed tent or chamber or from the breathing apparatus. The hypoxia induction system delivers oxygen-depleted air having between 5 to 20% Oto the enclosed tent or chamber or breathing apparatus. The system adjusts the oxygen content of the oxygen-depleted air being delivered to the enclosed tent or chamber or the breathing apparatus based upon the arterial oxygen saturation measured by the device such that oxygen saturation in the subject is maintained within a range of 50% to 90%.

Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders

Systems and methods for removing carbon monoxide from whole blood are provided. In one configuration, an extracorporeal phototherapy system includes an oxygenator and a light source configured to output light and arranged to emit the light output by the light source onto at least one surface of the oxygenator. The oxygenator includes a plurality of membrane layers each having a plurality of microporous hollow fiber membranes. The plurality of microporous hollow fiber membranes each include an external surface and an internal channel. Each of the plurality of membrane layers may be rotationally offset with respect to an adjacent layer. The oxygenator further includes a gas inlet port in fluid communication with a first end of the internal channels, a gas outlet port in fluid communication a second end of the internal channels, a blood inlet port, and a blood outlet port.

System and method for extracorporeal carbon monoxide removal with phototherapy

Systems and methods are provided for treating or preventing carbon monoxide poisoning. In particular, systems and methods are provided for a phototherapy treatment or prevention system that delivers light radiation to a patient's body to photodissociate carbon monoxide from hemoglobin.

System and method for phototherapy for preventing or treating carbon monoxide poisoning

Methods of promoting hypoxia or the hypoxia response for the treatment or prevention of mitochondrial dysfunction and oxidative stress disorders are described. Methods for screening for targets of mitochondrial dysfunction and oxidative stress disorders are also described.

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Boston, MA, United States of America

Luca Zazzeron