Sigea S.r.l.

Eurand Pharmaceuticals, Ltd.

Bmg Pharma LLC

Siega S.r.l.

Societa' Cooperative Centro Ricerche Poly-Tech a Responsabilita' Limitata

Same Deutz-Fahr Italia S.p.a.

Luca Stucchi

Marco Bosco

Fabrizio Picotti

Rita Gianni

Matteo Fabbian

Alessandro Rastrelli

Giuliana Miglierini

Alessandra Sechi

Luciano Navarini

Vladimir Vinkovic

Paolo Mariotti

Laurent Heraudet

Antonia Trevisan

Vitomir Sunjić

Alberto Perbellini

Regina Vesnaver

Ahmed Khan Riaz

The present invention relates to a process for the preparation of pharmaceutical, injectable or ophthalmic grade hyaluronic acid, or a salt thereof, for use in the dermocosmetic or pharmaceutical field or in medical devices, which comprises dissolution of hyaluronic acid or a salt thereof in organic solvent, a heat cycle, and recovery of the product by precipitation and successive washes in organic solvents.

Process for the purification of hyaluronic acid salt, conducted in organic solvent

The present invention relates to a process for the preparation of hyaluronic acid butyrate, or a salt thereof, acceptable for pharmaceutical or cosmetic use or as a medical device, comprising reacting hyaluronic acid, salified with sodium or another alkali metal, in aqueous solution with butyryl-imidazolide in the presence of sodium carbonate. The present invention also relates to pharmaceutical formulations, cosmetic formulations or medical devices containing the hyaluronic acid sodium salt (HA) butyric esters produced by said process.

Process in water for the preparation of butyric esters of hyaluronic acid sodium salt

Disclosed is the use of glycosaminoglycan esters, whose alcohol groups are partly esterified with lipoic acid or with lipoic acid and formic acid, in hair care treatments.

Use of glycosaminoglycan lipoate esters in the trichology field

Disclosed is the use of glycosaminoglycan esters, whose alcohol groups are partly esterified with lipoic acid or with lipoic acid and formic acid, in hair are treatments.

Non-crosslinked derivatives of oligo/polysaccharides of formula 

Polysaccharides derivatised with citric acid

Disclosed are acid polysaccharides characterized by the concomitant presence of alcohol groups esterified with butyric and formic acids.

Mixed butyric-formic esters of acid polysaccharides, and their preparation and use as skin cosmetics

Disclosed are polysaccharides containing residues of glucosamine or galactosamine in the repetitive unit, characterized by the presence of esters on the hydroxyls or amides on the amine functions, with lipoic acid or with mixtures of lipoic acid and formic acid.

Polysaccharide derivatives of lipoic acid, and their preparation and use as skin cosmetics and medical devices

Acid polysaccharides characterized by the concomitant presence of partial esters with non-polysaccharide carboxylic acids and esters between the acid groups of the initial polysaccharide and the alcohol groups of the repetitive units, with the formation of crosslinking among the polysaccharide chains.

Derivatives of acid polysaccharides

The invention describes new hyaluronan derivatives where the hydroxyl groups are esterified or carbamoylated in amounts ranging from 0.01% to 100% and the carboxyl groups are either totally or partially esterified with alcohols or are in the form of salt.

Derivatives of hyaluronan

The present invention relates to polysaccharidic esters of retinoic acid, wherein the hydroxyl groups of the monosaccharidic units of the polysaccharide are partially or totally esterified with retinoic acid. A process to obtain these esters is also described. The products according to the present invention can be used in the pharmaceutical and cosmetic field.

Polysaccharidic esters of retinoic acid

The present invention is related to polysaccharide esters of N-derivatives of glutamic acid (N-GA derivatives). These polysaccharidic esters have antiproliferative activity and are characterized by a low systemic toxicity. The esters of the invention are used in the prevention and therapy of diseases caused by cellular hyperproliferation, particularly psoriasis, tumors, rheumatoid arthritis, or intestinal inflammatory pathologies.

Polysaccharidic esters of N-derivatives of glutamic acid

A new class of polysaccharides containing carboxylic groups selectively substituted with halogens on the carbon atom on position 6 of the glicopyranosidic residue and the procedure to obtain these derivatives is therein described. The procedure entails the halogenation of carboxylated polysaccharides with alkyl aryl sulfonyl-halides in organic solvent. The products of this invention can be used as substrates in synthesis where the reactive site is the carbon that binds the halogen. Moreover, they can be used in the medical-diagnostic field.

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Pavia di Udine, Italy

Luca Stucchi