Euticals Prime European Therapeuticals Spa

Luca Giannini

Claudio Giordano

A method is described for the preparation of aryl-pyridine compounds of formula (I) by cross-coupling reaction, promoted by catalytic systems based on palladium or nickel between compounds of formula (II) and (III) in which: -Met represents Mg or Zn, &#x2014;Y represents Cl, Br, I or acetoxy, &#x2014;Z represents I, Br, Cl, triflate, sulphonate, phosphate, &#x2014;R, R, R, R, which are the same as one another or different, represent hydrogen, a linear and/or branched C-Calkyl, and/or an aryl, and/or a heteroaryl, or Rand Rand/or Rand R, taken together, form a C-Cring, an aryl and/or a heteroaryl, -A represents &#x2014;CORwhere Rrepresents hydrogen, a linear and/or branched C-Calkyl, and/or an aryl, and/or a heteroaryl, or -A represents &#x2014;CR(OR)(OR) where Rhas the meaning described above and Rand R, which are the same as one another or different, represent a linear and/or branched C-Calkyl, and/or an aryl, and/or a heteroaryl, or Rand R, joined together, represent a C-Calkyl or alkenyl. 

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Pavia, Italy

Luca Giannini