The University of Arizona

Invicro, LLC

Canon Kabushiki Kaisha

Luca Caucci

Harrison H Barrett

John William Hoppin

Yijun Ding

Liying Chen

Brian Miller

Akinori Ohkubo

Lars R Furenlid

The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.

Particle emission tomography

The present invention provides methods and systems for manipulating radiance data obtained from a radiance sensor that includes a lenslet array and a photodetector array, where the manipulation of the radiance data uses one or more algorithms or mathematical transformations applied by a software program. Manipulating the measured radiance data computationally produces the same optical effects of a desired optical system without having to insert the optical system into the optical path of the electromagnetic radiation. The manipulated radiance data is then used to generate an image.

Synthetic imaging systems using algorithms or mathematical transformations simulate optical effects of optical components

A radiance sensor includes a memory and a microprocessor. The memory stores non-transitory computer-readable instructions and adapted to store a plurality of electrical signals output from a photodetector array in response to electromagnetic radiation transmitted through a lenslet array and incident on the photodetector array. The microprocessor is adapted to execute the instructions to (i) determine irradiance of the electromagnetic radiation in a detector plane from the plurality of electrical signals, each electrical signal having generated by a respective one of a plurality of photodetectors of the photodetector array, and (ii) reconstruct, from the determined irradiance, the 4D-radiance in an input plane, the lenslet array being between the input plane and the detector plane.

Radiance sensor and radiance reconstruction method

The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.

Beta and alpha emission tomography for three-dimensional autoradiography

An apparatus for estimating a wavefront parameter includes a light source, a lenslet array, a detector for detecting light generated by the light source and passed through the lenslet array, a wavefront corrective element disposed between the lenslet array and the light source; and a data analyzer configured to estimate at least one wavefront parameter at a plane located on the light source side of the corrective element. The lenslet array and the sensor array are arranged to form a wavefront sensor, and the wavefront corrective element is configured to correct an aberration of the wavefront.

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Tucson, AZ, United States of America

Luca Caucci