Quimica Sintetica, S.a.

Chemo Iberica, S.a.

Luca Carcone

Giuseppe Barreca

Marcello Rasparini

Maurizio Taddei

Giovanni Marras

Elena Cini

Antonio Zanotti-Gerosa

Domenico Magrone

Fabio Morana

Damian Mark Grainger

Stephen James Roseblade

Norberto Masciocchi

Roberto Rocco Tufaro

Huang Liming

Samantha Louise Staniland

Claudio Cianferotti

Adele Russo

Renata Riva

Luca Banfi

Andrea Poggiali

Romina Vitale

Huan Liming

A highly pure form of ferric citrate and an industrially viable and advantageous process for its preparation are described.

Process for the preparation of ferric organic compounds

Industrially viable and advantageous processes for the preparation of Ozanimod are described. The invention also discloses the intermediates obtained in the process. 

Process for the preparation of sphingosine-1-phosphate receptor agonist

The invention relates to an industrially viable and advantageous process for the preparation of (2S,3 R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid, having the following formula (I) generally known as Droxidopa, or of intermediates useful in the synthesis thereof. 

Processes for the preparation of diastereomerically and enantiomerically enriched oxazolines

Two processes are described for preparing, in different diastereomeric purity degrees, the compound (S)-isopropyl-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)-phosphoryl)amino) propanoate, having the formula given below, known as Sofosbuvir and used for the treatment of hepatitis C. 

Nucleoside phosphoramidates useful for the treatment of viral infections and preparation thereof

A new route of synthesis of the compound Aliskiren of formula (I), used in the treatment of hypertension, is described. 

Process for producing Aliskiren

It is described a process for the opening of lactone or lactam rings useful in the synthesis of pharmaceutically active compounds and the intermediates thereof, particularly Aliskiren. It has found that by selecting a type of solvent it is possible to obtain excellent yields and high optical and chemical purity of the isolated products.

Chemical process for opening ring compounds

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Milan, Italy

Luca Carcone