UniversitÉ Libre De Bruxelles

Bioxodes Sa

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Faculté Universitaire Des Sciences Agronomiques De Gembloux

Luc Vanhamme

Edmond Godfroid

Alex Bollen

Yves Decrem

Gerard Leboulle

Robert Brasseur

Etienne Pays

Laurence Lins

Jérôme Beaufays

Benoît Adam

Sébastien Santini

Gérard Leboulle

Francoise Paturiaux-Hanocq

Philippe Poelvoorde

The invention relates to a new polynucleotide which encodes a polypeptide expressed in the salivary glands of ticks, more particularly thearthropod tick, during the slow-feeding phase of the blood meal have, said polynucleotide and related polypeptide may be used in different constructions and for different applications which are also included in the present invention.

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Leukotriene B4 binding polypeptide is obtained from Ixodes ricinus. Leukotriene B4 polypeptide, the polynucleotide encoding Leukotriene B4 polypeptide, and Leukotriene B4 polypeptide related polypeptides may be used as research reagents and for treatments and diagnostics specific to animal and human diseases.

Leukotriene B4 binding soluble lipocalin receptor from ixodes ricinus

The invention relates to a new polynucleotide which encodes a polypeptide expressed in the salivary glands of ticks, more particularly thearthropod tick, during the slow-feeding phase of the blood meal have. The polynucleotide and related polypeptide may be used in different constructions and for different applications which are also included in the present invention.

The present invention is related to a composition comprising apolipoprotein L-l, the use of apolipoprotein L-l or a derivated polypeptide for the diagnostic, the treatment and/or the prevention of diseases induced in mammals by. Another aspect is related to a transgenic non-human mammal comprising a polynucleotide expressing the apolipoprotein L-l or a derivated polypeptide and which is tolerant or resistant to theinfection.

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Court-Saint-Etienne, Belgium

Luc Vanhamme