Symetis Sa

Boston Scientific Scimed, Inc.

Boston Scientific Corporation

Boston Scientific Medical Device Limited

Luc Mantanus

Jean-Luc Hefti

Stephane Delaloye

Jacques Essinger

Fabien Lombardi

Youssef Biadillah

Stéphane Delaloye

Pierre Simonin

Jean-luc Hefti

Michael Paris

Lionel Flaction

Reynald Passerini

Yutit Wanakoht

Iker Mallabiabarrena

A delivery catheter for a stent. The delivery catheter may comprise a distal end and a proximal end. The distal end includes a stent attachment region adapted to receive a stent. The stent may be of the self-expanding type. The catheter further comprises a handle at its proximal end and at least one sheath which may at least partially circumferentially cover said stent such as to retain it in a collapsed configuration. The sheath is coupled at its proximal end to an actuator located on said handle portion.

Catheter delivery system for stent valve

Apparatus () for compressing a transcatheter cardiac stent-valve () comprises: a first compressor stage () including a hollow channel () with a tapered interior surface configured for compressing a stent-valve in response to longitudinal advancement of the stent-valve within the channel; and a second compressor stage () comprising a crimper for compressing a portion of the stent-valve without longitudinal advancement.

Method and apparatus for compressing/loading stent-valves

Some embodiments of the present disclosure provide a stent-valve for transcatheter implantation to replace a cardiac valve. In some embodiments, the stent valve being compressible to a compressed state for delivery, and expandable to an operative state for implantation. In some embodiments, the stent-valve comprises a stent, a plurality of leaflets for defining a prosthetic valve, an inner skirt, an outer skirt, and a paravalve seal for sealing against surrounding tissue. In some embodiments, the paravalve seal comprising material that swells in response to contact with blood or components thereof.

Relating to transcatheter stent-valves

A delivery catheter for a prosthetic heart valve, the valve expandable from a collapsed condition for delivery to an expanded condition for implantation, the delivery catheter comprising: a holder for engaging the valve in the collapsed state of the valve, the holder configured such that (i) in response to a radial compression force exerted thereon, the holder has a first shape defining an exposed engagement region for engaging at least a portion of the collapsed prosthetic heart valve for restraining axial displacement of the prosthetic valve in at least one axial direction of the catheter, and (ii) in response to removal of the radial compression force upon expansion of the valve, at least a portion of the holder transitions to a second shape.

Prosthetic valve. delivery apparatus and delivery method

Apparatus () for compressing a transcatheter cardiac stent-valve () comprises: a hollow channel () having an interior surface () shaped for progressively compressing the stent-valve in response to longitudinal advancement of the stent-valve within the channel; a driver () threadedly engaged on the exterior of the channel for generating a longitudinal driving force in response to rotation; a mover () having limbs () that project through slots () in the channel wall to transmit the driving force to the stent-valve within the channel; and a channel extension () removably attachable at the exit () to provide a generally cylindrical containment bore ().

A delivery catheter () for a stent valve (), the delivery catheter having a distal portion () insertable into an anatomy, the distal portion comprising an accommodation region () for accommodating a stent-valve for delivery into the anatomy, the delivery catheter further comprising at least one sheath () that is translatable between a closed position for at least partly closing the accommodation region and an open position for at least partly opening the accommodation region.

Stent valve, delivery apparatus and method therefor

Transcatheter stent-valves and methods, systems and devices for addressing para-valve leakage

A stent-valve for transcatheter implantation to replace a cardiac valve, the stent valve being compressible to a compressed state for delivery, and expandable to an operative state for implantation, the stent-valve comprising a stent, a plurality of leaflets for defining a prosthetic valve, an inner skirt, an outer skirt, and a paravalve seal for sealing against surrounding tissue. In some embodiments, the paravalve seal comprises material that swells in response to contact with blood. In some embodiments, the seal comprises a flap or pocket that is distensible in response to backpressure and/or paravalve back-flow of blood.

Transcatheter stent-valves

A delivery apparatus for delivering a stent-valve for implantation within the body, the delivery apparatus configured for introduction into the body through an arterial introducer of a type having a stem insertable into the body and a mouth section that remains outside the body, the mouth section including a haemostasis valve, and wherein the delivery apparatus comprises: a first constraining sheath at a stent-valve accommodation region of the apparatus at a distal end of the apparatus, and configured for constraining at least a portion of a stent-valve at the accommodation region in a radially collapsed configuration; a delivery introducer captive on the delivery apparatus, and slidable between a first position surrounding at least a portion of the stent-valve accommodation region, and a second position in which the delivery introducer slides proximally of the stent-valve accommodation region; wherein the delivery introducer is insertable at least partly into the mouth of a said arterial introducer, the delivery introducer configured for introducing the stent-accommodation region through the haemostasis valve.

Stent-valve, delivery apparatus and method of use

Embodiments of the present disclosure are related to devices and techniques for para-valve sealing of an expandable stent-valve implanted using a catheter. In some embodiments, a stent-valve is provided which comprises a seal sleeve/cuff containing material that swells when contacted by blood. A piercing tool may be included and used to permit a user to puncture the sleeve/cuff prior to introduction into a patient's body. In some embodiments, the sleeve/cuff has an integral tubular structure configured to withstand balloon expansion of the stent-valve during or after implantation. In some embodiments, the seal is provided as a separate component from the stent-valve.

Prosthesis seals and methods for sealing an expandable prosthesis

Embodiments of the present disclosure are directed to stents, valved-stents, and associated methods and systems for their delivery via minimally-invasive surgery.

Growing community of inventors

Lausanne, Switzerland

Luc Mantanus