Université Pierre Et Marie Curie (paris Vi)

Arteriocyte Inc.

Centre National De La Recherche Scientifique

Assistance Publique-hopitaux De Paris

Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris

Université Pierre Et Marie Curie

Etablissement Francais Du Sang

Luc Douay

Hai-Quan Mao

Kevin D McIntosh

Jérôme Bibette

Nicolas Bremond

Jean Baudry

Hugo Domejean

Ramasamy Sakthivel

Donald J Brown

Vincent J Pompili

Hiranmoy Das

Yukang Zhao

Marie-Catherine Giarratana

Maria Catalina Giarratana

Julie Victoire Brouchon

The invention provides, among other things, methods and systems for expanding CD133+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in a subject in need thereof, such as to ischemic myocardium. The invention further provides methods and systems for directing differentiation of expanded CD133+ cells. The invention further provides methods and systems for treating a subject with differentiated cells in a subject in need thereof.

Erythrocytes differentiated in vitro from nanofiber expanded CD133+ cells

The invention relates to a method for the expansion and differentiation of haematopoietic stem cells into enucleated erythrocytes, in two steps: a first step in a culture medium, where cell proliferation and erythmid differentiation are induced in the presence of growth factors, and a second step modeling a reconstitution of the microenvironment, substantially without erythropoietin (EPO). Optionally, the method of culture may comprise an intermediate step, with haematopoietic growth factors.

Method for producing red blood cells

Growing community of inventors

Paris, France

Luc Douay