Aventis Pharma S.a.

Sanofi

Sanofi-aventis

Luc Bertin

Patrick Mailliet

Jean-Marie Ruxer

Fabienne Thompson

Maria Mendez-Perez

Chantal Carrez

Fabienne Pilorge

Didier Benard

Frank Halley

Eric Bacque

Victor Certal

Hervé Minoux

Marcel Alasia

Stephane Hourcade

Hélène Goulaouic

Peter Hamley

François Vallee

Francois Vallee

Thierry Gouyon

Stéphane Hourcade

Maria Mendez-perez

The invention relates to the novel substances in Formula (I): wherein Het is a heterocycle optionally substituted by one or a plurality of radicals R1 or R'1; R is selected from the group comprising Formula (A&#x2032;), (B), (C), (D), or (E), with R1 and/or R&#x2032;1 selected from H, halogen, CF3, nitro, cyano, alkyl, hydroxyl, mercapto, amino, alkylamino, dialkylamino, alkoxy, phenylalcoxy, alkylhio, or carboxy that is free or esterified by an alkyl, carboxamide, CO&#x2014;NH(alkyl), CON(alkyl)2, NH&#x2014;CO-alkyl, sulfonamide, NH&#x2014;S02-alkyl, S(0)2-NHalkyl, or S(02)-N(alkyl)2 radical; all these radicals are optionally substituted; W1, W2, and W3 independently are CH or N; X is 0, S, NR2, C(O), S(O), or S(0)2; Z is optionally substituted H, Hal, -0-R2 or &#x2014;NH&#x2014;R2 with R2 being H, alkyl, cycloalkyl, or heterocycloalkyl; and these substances are all isomeric forms and salts thereof, used as drugs. 

HSP90 inhibitory carbazole derivatives, compositions containing same and use thereof

The present invention relates to compounds of formula (I): wherein R1, R, R', L, Het, p and p&#x2032; are as defined herein, compositions containing them, and their use as medicinal products.

Fluorene derivatives, compositions containing the same and use thereof as inhibitors of the protein chaperone HSP 90

This invention relates to isoindole derivates of Formula I to pharmaceutical compositions comprising such derivatives, and to methods of treatment comprising administering of such derivatives.

Isoindole derivatives, compositions containing same, preparation thereof and pharmaceutical uses thereof in particular as inhibitors of chaperone protein Hsp90 activities

This invention relates to derivatives of 4-(benzimidazol-2-yl)fluorene and 4-(azabenzimidazol-2-yl)fluorene, to pharmaceutical compositions comprising such derivatives, and to methods of treatment of disorders related to Hsp90 protein activity, comprising administering such derivatives.

Fluorene derivatives, composition containing said derivatives and the use thereof

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Paris, France

Luc Bertin