Mendel Biotechnology, Inc.

Epitomics, Inc.

Monsanto Technology LLC

Swetree Technologies Ab

Luc Adam

Oliver J Ratcliffe

T Lynne Reuber

Robert A Creelman

Jacqueline E Heard

Cai-Zhong Jiang

Jose Luis Riechmann

Omaira Pineda

Guo-Liang Yu

Frederick D Hempel

Roderick W Kumimoto

James Z Zhang

Karen S Century

Neal I Gutterson

Peter P Repetti

Marsha L Pilgrim

Arnold N DuBell, Iii

Pierre Broun

Roger D Canales

James S Keddie

Bradley K Sherman

Raymond R Samaha

Jeffrey M Libby

Volker Haake

Pierre E Broun

Hans E Holtan

Shiv Bahadur Tiwari

Graham J Hymus

Katherine Krolikowski

Colleen M Marion

Suqin Cai

Mark Bushfield

Michael Hadjisavas

Marjorie R Lundgren

Lynne Reuber

Amanda J Burek

Megan Lau

Bonnie R Brayton

Yu Shen

Weimin Zhu

Magnus Hertzberg

Michael Fromm

Emily L Queen

Torgny Näsholm

Joseph Michael Palys

Karin Vroom

Li Wei

Jennifer M Costa

Tracy A Morrison

Arnold Dubell

Liang Xiang

Lynne T Reuber

Peter Repetti

A method of screening is provided. In certain embodiments, the method involves a) obtaining the nucleotide sequences of: i. a heavy chain-encoding nucleic acid that encodes the variable domain of a heavy chain of a first antibody of an animal; and ii. a light chain-encoding nucleic acid that encodes the variable domain of a light chain of the first antibody; b) obtaining nucleotide sequences of cDNAs encoding at least a portion of the antibody repertoire of the animal; c) computationally screening the sequences obtained in b) to identify heavy and light chain sequences that are related by lineage to the heavy and light chain sequences of a); and d) testing at least one pair of the heavy and light chain sequences identified in c) to identify a second antibody that binds to the same antigen as the first antibody.

Antibody identification by lineage analysis

Provided herein, inter alia, is a method for producing an enriched population of antigen-specific plasma cells. In some embodiments, the method may comprise: (a) obtaining a sample of cells from an animal that has been immunized by an antigen, wherein the sample comprises B cells; (b) enriching for a population of antigen-specific B cells that comprise cell surface antibodies that are specific for the antigen by: i. contacting at least 105 of the cells in said sample, en masse, with the antigen or a portion thereof; and ii. isolating cells that bind to the antigen or portion thereof; and (c) activating the enriched B cells, en masse, in the presence of the antigen or portion thereof, to produce the enriched population of antigen-specific plasma cells.

High throughput monoclonal antibody generation by B cell panning and proliferation

Transcription factor polynucleotides and polypeptides incorporated into nucleic acid constructs, including expression vectors, have been introduced into plants and were ectopically expressed. Transgenic plants transformed with many of these constructs have been shown to be more resistant to disease (in some cases, to more than one pathogen), or more tolerant to an abiotic stress (in some cases, to more than one abiotic stress). The abiotic stress may include, for example, salt, hyperosmotic stress, water deficit, heat, cold, drought, or low nutrient conditions.

Stress tolerance in plants

The application describes producing polynucleotide variants of the AtHB 17 clade members and introducing the mutant variants into plants to improve plant traits. The mutant polynucleotides encode polypeptides that comprise mutations in the EAR motifs.

Mutation of the EAR motif of class II HD-ZIP polypeptides

The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having improved tolerance to drought, shade, and low nitrogen conditions, as compared to wild-type or reference plants.

Plant transcriptional regulators

Mutation of the ear motif of class II HD-Zip polypeptides

The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.

Polynucleotides and polypeptides in plants

Transcription factor polynucleotides and polypeptides incorporated into nucleic acid constructs, including expression vectors, have been introduced into plants and were ectopically expressed. Transgenic plants transformed with many of these constructs have been shown to have increased tolerance to an abiotic stress (in some cases, to more than one abiotic stress), increased growth, and/or increased biomass. The abiotic stress may include, for example, salt, hyperosmotic stress, water deficit, heat, cold, drought, and/or low nutrient conditions.

G748 transcription facter for improving plant growth

The invention is directed to transgenic plants transformed with nucleic acids that encode a plant transcription factor that increases the transgenic plant's size and yield and/or delays flowering in the plant, and methods of using and producing the transgenic plants.

Transcription factors for increasing yield

MYB-related transcriptional regulators that confer altered root hare, trichome morphology, and increased tolerance to abiotic stress in plants

The invention relates to plant AP2 protein family polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties, including greater tolerance to freezing, as compared to a reference plant.

Yield-related polynucleotides and polypeptides in plants

Growing community of inventors

Hayward, CA, United States of America

Luc Adam