Actelion Pharmaceuticals Ltd

Idorsia Pharmaceuticals Ltd

Lubos Remen

Corinna Grisostomi

Daniel Bur

Martin Bolli

John Gatfield

Cornelia Zumbrunn

Thomas Weller

Sylvia Richard-Bildstein

Olivier Bezencon

Christoph Sager

Thierry Sifferlen

Walter Fischli

Olivier Corminboeuf

Christoph Boss

Oliver Nayler

Michel Therien

Daniel Dube

Magali Vercauteren

Richard Welford

John Scheigetz

Dan McKay

Dwight MacDonald

Austin Chih-Yu Chen

Walter Fiśchli

David Powell

Hans-Peter Weber

Sylvia Richard

The present invention relates to compounds of Formula (I) wherein Ar, R, R, R, and Rare as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.

(2-acetamidyl)thio-beta-D-galactopyranoside derivatives

The present invention relates to compounds of Formula (I) wherein Ar, Ar, R, R, and Rare as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.

(Hetero)aryl-methyl-thio-beta-D-galactopyranoside derivatives

The present invention relates to compounds of Formula (I) wherein Ar, Rand Rare as described in the description, and A is 4,5-dihydroisoxazole-3,5-diyl, imidazolidin-4-one-1,3-diyl, oxazol-2-one-3,5-diyl and oxazolidine-2-one-3,5-diyl, 1,2,3-triazole-1,4-diyl, isoxazole-3,5-diyl, imidazole-1, 4-diyl, and isothiazole-3,5-diyl; and their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.

Alpha-D-galactopyranoside derivatives

The present invention relates to compounds of Formula (I) wherein Ar, A, B, and Rare as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.

Spiro derivatives of Alpha-D-galactopyranosides

The present invention relates to compounds of Formula (I) wherein X, Ar, Ar, L, n, m, and Rare as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.

Hydroxyheterocycloalkane-carbamoyl derivatives

The present invention relates to compounds of Formula (I)

2-hydroxycycloalkane-1-carbamoyl

The present invention relates to compounds of Formula (I) wherein Ar, Ar, L, n, and Rare as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.

Galectin-3 inhibiting 2-hydroxycycloalkane-1-carbamoyl derivatives

The present invention relates to compounds of the formula (I) wherein R, R, R, R, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

Tricyclic imidazole compounds as inhibitors of tryptophan hydroxylase

The present invention relates to compounds of the formula (I) wherein R, R, R, R, R, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

Tricyclic piperidine compounds

The invention relates to novel bicyclononene derivatives of Formula (I); and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin. 

Bicyclononene derivatives

The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

Secondary amines as renin inhibitors

The invention relates to a novel 3,9-diazabicyclo[3.3.1]nonene derivative of formula (I), enantiomers thereof, and their use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing at least one compound of formula (I): or (I'): and especially their use as inhibitors of renin.

Diazabicyclononene derivatives and use thereof

The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these novel compounds, pharmaceutical compositions comprising such compounds and especially the use of such compounds as inhibitors of renin.

Piperidine carboxylic acid amide derivatives

The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin. 

7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases

Growing community of inventors

Allschwil, Switzerland

Lubos Remen