Emory University

The Florida State University Research Foundation, Inc

Children's Healthcare of Atlanta, Inc.

Children's Heatlhcare of Atlanta

Lubing Gu

Binghe Wang

Chunhao Yang

Chaofeng Dai

Nanting Ni

Weixuan Chen

Alexander Draganov

Xiaochuan Yang

Guojing Sun

Muxiang Zhou

Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.

Anthraquinone analogs and methods of making and using thereof

Growing community of inventors

Tucker, GA, United States of America

Lubing Gu