Affymetrix, Inc.

Affymax Technologies, N.v.

Leland Stanford Junior University

Senomyx, Inc.

Lubert Stryer

Michael C Pirrung

J Leighton Read

Stephen P A Fodor

Stephen P Fodor

James L Winkler

Christopher P Holmes

Glenn H McGall

Richard P Rava

Martin J Goldberg

Alexander N Glazer

Virginia W Goss

R Fabian Pease

Mark S Chee

Ronald W Barrett

Dennis Solas

Steven A Sundberg

Thomas R Gingeras

David H Mack

Anthony J Berno

Ghassan Ghandour

Paul D Hoeprich, Jr

Vernon T Oi

Ching Wang

Sergey Zozulya

Earl A Hubbell

Richard A Mathies

Konan Peck

Stephen Pa Fodor

The use of sensory G protein-coupled receptors that recognize chemical sensants, parti-cularly those involving olfactory and taste receptors; polypeptide fragments and mutants thereof; classes of such receptors; polynucleotides encoding such receptors, fragments and mutants thereof, and representatives of receptor classes; genetic vectors including such polynucleotides; and cells and non-human organisms engineered to express such receptor complexes, fragments and mutants of an olfactory or taste receptor, and representatives of receptor classes to simulate sensory perception of odorants and tastants is described. The use of such products as a biosensor or a component thereof to detect, identify, measure, or otherwise process the event of binding between the receptor and its cognate ligand (i.e., chemical sensant) is also described. The invention has application, for example, in the design and formulation of odorant and tastant compositions.

Receptor fingerprinting, sensory perception, and biosensors of chemical sensants

This invention provides oligonucleotide based arrays and methods for speciating and phenotyping organisms, for example, using oligonucleotide sequences based on therpoB gene. The groups or species to which an organism belongs may be determined by comparing hybridization patterns of target nucleic acid from the organism to hybridization patterns in a database.

Chip-based speciation and phenotypic characterization of microorganisms

A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.

Nucleotides and analogs having photoremovable protecting groups

A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.

Apparatus comprising polymers

This invention provides oligonucleotide based arrays and methods for speciating and phenotyping organisms, for example, using oligonucleotide sequences based on thegene. The groups or species to which an organism belongs may be determined by comparing hybridization patterns of target nucleic acid from the organism to hybridization patterns in a database.

Chip-based species identification and phenotypic characterization of microorganisms

The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.

Polypeptide arrays

A library for determining the sequence of monomers in a polymer which is complementary to a receptor includes groups of pooled polymer products; wherein each pool is ordered such that a monomer sequence which binds to a receptor can be identified from the pool order in the library.

Factorial chemical libraries

A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.

Methods for polymer synthesis

A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier material, among other materials. The method and apparatus also relies upon standard DMT based chemistry, and a vapor phase deprotection agent such as solid TCA and the like.

Printing oligonucleotide arrays

Nucleic acid reading and analysis system

Methods of synthesizing a plurality of different polymers on a surface of a substrate

Support bound probes and methods of analysis using the same

Methods of making nucleic acid or oligonucleotide arrays

Very large scale immobilized polymer synthesis

Growing community of inventors

Stanford, CA, United States of America

Lubert Stryer