Janssen Biotech, Inc.

Centocor Ortho Biotech Inc.

Lu Lu

Chichi Huang

Jinquan Luo

Ellen Chi

Ronald Swanson

Galina Obmolova

Jarrat Jordan

Xiefan Lin-Schmidt

Christian Martinez

Judith Ann Connor

The present invention relates to antibodies that broady neutralize interferon-&#x3b1; and interferon-&#x3c9;, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.

Interferon alpha and omega antibody antagonists

Interferon &#x3b1; and &#x3c9; antibody antagonists

Broadly neutralizing interferon-&#x3b1; and interferon-&#x3c9; antibody antagonists, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing are useful in the treatment of diseases associated with increased production of IFN&#x3b1; and IFN&#x3c9;.

Improved bacterial secretion signals derived from pelB and ompA are provided. The improved variants enhance bacterial membrane secretion are thus useful for production of proteins secreted from bacteria including proteins displayed on filamentous phage particles, and, in particular, proteins requiring oxidative formation of covalent bonds, such as disulfide bonds within or between polypeptide chains in order to form a correctly folded and functional protein structure. Described herein are methods for the multivalent display of complex dimeric proteins on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion polypeptide with filamentous phage pIX coat protein. Heterodimeric or more complex interchain bonded structures may also be displayed using the method of the invention.

Bacterial membrane protein secretion

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San Diego, CA, United States of America

Lu Lu