University of Oklahoma

Janssen Pharmaceutica

Other

Loyd V Allen, Jr

Bingnan Wang

John Desmond Davies

A conducting silicone matrix incorporating a suspension of a drug in ionized and non-ionized phases in an emulsion of a hydrophobic polymer. In one version, the drug is prepared as a concentrated aqueous suspension incorporated in a silicone matrix with a silicone surfactant. An electrolyte may be incorporated into the silicone matrix for increasing its conductivity. When a current is applied, the drug in individual globules in the drug suspension migrates away from the electrode and becomes concentrated at the distal side of the globules eventually resulting in an increase in the drug concentration distal to the electrode and adjacent to the skin and thereby resulting in transfer of the active drug through the skin. This system provides a matrix with minimal electroendosmotic flow that is current efficient and provides a drug reservoir that can last for several days during application of the drug.

Iontophoretic transdermal delivery device

A particulate support matrix, and a dosage form made therefrom, and processes for making such support matrices and dosage forms, which disintegrate or dissolve in a matter of just a few seconds once placed into an aqueous environment. First, a porous particulate powder matrix comprising at least two polymeric components which will serve as the dosage form matrix is produced. The polymeric components have different solubilities. In a second step, a pharmaceutical compound, for example an antihistamine, decongestant, or antibiotic is combined with the powder. Other additives may also be added to the mixture. In a third step the mixture is formed into a dosage form. Finally, in a fourth step, a coating may be formed upon the outer surface of the dosage form to enhance the intactness and durability of the dosage form.

Process for making a particulate support matrix for making a rapidly dissolving dosage form

Rapidly dissolving dosage form

Particulate support matrix for making a rapidly dissolving dosage form

A particulate support matrix, and a dosage form made therefrom, and processes for making such support matrices and dosage forms, which disintegrate or dissolve in a matter of just a few seconds once placed into an aqueous environment. First, a porous particulate powder matrix which will serve as the dosage form matrix is produced. In a second step, the pharmaceutical, for example an antihistamine, decongestant, or antibiotic is combined with the powder. Other additives may also be added to the mixture. In a third step the mixture is formed into a dosage form. Finally, in a fourth step, a coating may be formed upon the outer surface of the dosage form to enhance the intactness and durability of the dosage form.

Method for producing a rapidly dissolving dosage form

The present invention comprises a tablet, and method for making such, which disintegrates or dissolves in a matter of just a few seconds once placed into the oral cavity. Generally, the method of the present invention comprises up to four steps. First, a porous particulate powder which will serve as the tablet support matrix is produced. In the second step, the pharmaceutical, for example an antihistamine, decongestant, or antibiotic is combined with the powder. Other additives may also be added to the mixture. In the third step the mixture is formed into a tablet. Finally, in the fourth step, a coating may be applied to the outer surface of the tablet to enhance the intactness and durability of the tablet.

Rapidly dissolving tablet

The present invention concerns a particulate support matrix, a solid dosage form made therefrom, and processes for making such support matrices and dosage forms, which disintegrate or dissolve in a matter of just a few seconds once placed into the oral cavity. First, a porous particulate powder which will serve as the tablet support matrix is produced. In the second step, the pharmaceutical, for example an antihistamine, decongestant, or antibiotic is combined with the powder. Other additives may also be added to the mixture. In the third step the mixture is formed into a tablet. Finally, in the fourth step, a coating may be applied to the outer surface of the tablet to enhance the intactness and durability of the tablet.

Method of making a rapidly dissolving tablet

The present invention comprises a particulate support matrix for making a solid tablet form, and method for making such, which disintegrates or dissolves in a matter of just a few seconds once placed into the oral cavity. Thee particulate support matrix comprises a first polymeric component which may be a polypeptide, preferably a non-hydrolyzed gelatin, a second polymeric component which may be a different polypeptide which may be a hydrolyzed gelatin and a bulking agent. The porous particulate powder can serve as the tablet support matrix, to which a pharmaceutical, for example an antihistamine, decongestant, or antibiotic is added.

Particulate support matrix for making a rapidly dissolving tablet

The present invention comprises a particulate support matrix for making a tablet, and method for making such, which disintegrates or dissolves in a matter of just a few seconds once placed into the oral cavity. Thee particulate support matrix comprises a first polymeric component which may be a polypeptide, preferably a non-hydrolyzed gelatin, a second polymeric component which may be a different polypeptide which may be a hydrolyzed gelatin and a bulking agent. The porous particulate powder can serve as the tablet support matrix, to which a pharmaceutical, for example an antihistamine, decongestant, or antibiotic is added.

Growing community of inventors

Edmond, OK, United States of America

Loyd V Allen, Jr