Burroughs Wellcome Co.

Lowrie M Beacham, Iii

Susan Mary Daluge

Thomas A Krenitsky

Gertrude B Elion

John W Selway

Joel Van Tuttle

George A Freeman

Harry S LeBlanc

Janet E Litster

2',3'-Dideoxy-3'-fluoro pyrimidine nucleosides particularly 2',3'-dideoxy-3'-fluorothymidine have been found to have particularly potent activity against adenovirus infections especially those caused by adenoviruses of serotype 8. Such compounds are preferably presented in pharmaceutical formulations adapted for ophthalmic administration.

Antiviral compounds

Treatment of susceptible gram-negative infections in animals is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of the 5'-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose.

Antibacterial treatment

This invention relates to purine sugar derivatives which are useful as suppressors of the immune response and as antiviral agents, and to methods of preparation thereof.

Purine sugar derivatives

Growing community of inventors

Durham, NC, United States of America

Lowrie M Beacham, Iii