Johnson & Johnson Medical Gmbh

Ethicon, Gmbh

Celanese Gmbh

Johnson & Johnson Products, Inc.

Other

Johnson & Johnson Patient Care, Inc.

Xylos Corporation

Lowell G Saferstein

Stephen J Wolf

David M Wiseman

Rao S Bezwada

Joel S Rosenblatt

Leslie Hamilton

Robert W Stackman

Mark B Roller

Murty Narayan Vyakarnam

Semyon Shchervinsky

Robert E Maurer

Michael M Besso

Gonzalo Serafica

Albert R Kelly

James F Martin

Franklin Boardman

Ram L Kataria

David A Dalessandro

Elaine J Whitmore

Cary B Linsky

Alex B Ilori

Julius A Lindquist

Reginald L Stilwell

Michael J Ram

Lola Kamp

Andrew J Manning

This invention relates to a process for preparing bioabsorbable oxidized cellulose comprising combining cellulose material, with nitrogen dioxide and a nonaqueous solvent chosen from the class of perfluorinated tertiary amines. This invention also relates to a method of oxidizing cellulose material comprising introducing a solvent into the vessel, circulating the solvent through the cellulose material, adding nitrogen dioxide to said vessel containing the solvent and cellulose in the required amounts, circulating the solution for 7 to 24 hours while controlling the reaction temperature, and isolating the oxidized material. Preferably, isolation of the oxidized product is followed by first washing the oxidized cellulose material with cold water, then washing the oxidized cellulose material with an aqueous alcohol solution several times, then washing the material with 100% alcohol several times, and finally drying the oxidized material.

Cellulose oxidation by nitrogen dioxide in a perfluorinated tertiary amine solvent

An improved adhesion-preventative physical barrier, wound dressing and drug delivery system comprising an oxidized cellulose film made up of multiple layers of a cellulose fabric or like material and a cellulose film. A method for forming an improved oxidized cellulose film and for using the same to prevent the formation of postsurgical adhesions and/or to dress a wound and/or to deliver one or more drugs.

Bioresorbable oxidized cellulose composite material for prevention of postsurgical adhesions

An apparatus for achieving hemostasis and pneumostasis along a staple line by utilizing a compliant bioabsorbable foam buttress which may be attached to one jaw of a surgical stapling apparatus by a biocompatible releasable adhesive.

Foam buttress for stapling apparatus

An electrical connector for a cardiac device is disclosed. The connector has a wire and an electrode at the distal end of the wire. The wire is attached to a patch, and the patch is coated with an adhesive film for adhering the patch to tissue. The preferred connector is a bipolar temporary cardiac pacing wire. The use of an adhesive film eliminates or reduces the need for suturing the patch to tissue, thus avoiding or significantly reducing tissue trauma associated with suturing.

Electrical connector for cardiac devices

A substantially flexible, dry matrix with antimicrobial properties is made from a matrix comprising natural or synthetic, woven, non-woven or knitted fibers, said matrix having been uniformly coated with an amount of a non-aqueous treatment solution sufficient to allow said matrix to retain its substantially dry characteristics. In a preferred embodiment, said non-aqueous treatment solution has between about 70% and 99% of at least one glycol compound, between about 1% and 15% of a PVP-iodine and optionally between about 0 and 15% of a non-ionic surfactant. Also, skin is treated to prevent disease, such as the disinfecting of teats on dairy cows during milking, by wiping the skin with the article.

Substantially anhydrous antiseptic wipes

A hemostatic paste composition comprising a hemostatic effective amount of thrombin in a polyethylene glycol base which is preferably prepared by admixing an aqueous solution of thrombin and polyethylene glycol and freeze-drying the mixture to remove substantially all of the water to yield a viscous water soluble paste of fine particles of thrombin uniformly dispersed throughout the polyethylene glycol base, and methods of its use to provide hemostasis to a hemorrhaging site of a mammal.

Hemostatic thrombin paste composition

A calcium-modified oxidized cellulose hemostat provides faster hemostasis than does either unmodified or sodium- or potassium-modified oxidized cellulose. The percentage by weight of calcium in the modified oxidized cellulose must be in a range between about 0.5 and about 4, in order to enhance hemostasis, while not interfering excessively with bioabsorbability. In a second embodiment, an oxidized cellulose hemostat is modified with both calcium and either sodium or potassium. The second embodiment may be used to deliver acid-sensitive materials.

Calcium-modified oxidized cellulose hemostat

A process for oxidizing cellulose involves reacting the cellulose with a solution of nitrogen dioxide in a perfluorocarbon solvent. In preferred embodiments, the solvent has a boiling point in the range between about 30.degree. C. and 100.degree. C., the nitrogen dioxide concentration in the solution is in the range between about 2% and 12% by weight, and the reactants are maintained at a temperature between about 25.degree. C. and 60.degree. C. during a reaction time fo at least about 7 hours.

Cellulose oxidation by a perfluorinated hydrocarbon solution of nitrogen

Oxidized cellulose material is neutralized, by contacting an acidic oxidized cellulose material with a water and alcohol solution of a basic salt of a weak organic acid, e.g. sodium acetate, to elevate the pH of the cellulosic material to between 5 and 8. The resulting neutralized product is storage stable and has therapeutic applications, including hemostasis and adhesion prevention. Furthermore, the neutralized product may be impregnated with acid-sensitive hemostatic agents, such as thrombin, to enhance its hemostatic properties, or with acid-sensitive adhesion-preventive agents, such as t-PA, to enhace its adhesion-prevention properties.

Process for preparing a neutralized oxidized cellulose product and its

A hemostatic collagen paste composition comprising a mixture, by weight of the total composition, of 2 to 30% of crosslinked collagen powder of 10 to 100 mesh particle size and 30 to 98% of water or an aqueous saline solution and hemostatic paste compositions that also comprise a hemostatic enhancing amount of thrombin, as well as methods of making and using such hemostatic collagen paste compositions.

Hemostatic collagen paste composition

A process is disclosed for delivery thrombin in dry powdered form from an aerosol container by first lyophilizing an aqueous solution of thrombin and a thrombin-compatible synthetic polymer e.g. polyvinyl pyrrolidone, placing the lyophilized cake in a pressure bottle by crimping on a valve stem and top, filling liquified chlorofluoroalkane-containing aerosol propellant into the bottle, and actuating the valve to dispense in dry-finely divided powdered form a mixture of thrombin and polyvinyl pyrrolidone, which powdered thrombin is for use in controlling bleeding during surgery.

Thrombin aerosol

Hemostatic adhesive bandages are disclosed wherein a very thin coating of a high molecular weight polyethylene oxide is applied to the surface of the perforated plastic film wound release cover of an adhesive bandage, in a manner compatible with commonly used high speed production techniques and equipment, which stop the bleeding faster when applied to minor cuts.

Hemostatic adhesive bandage

The present invention relates to a process for preparing certain halogenated aromatic polyesters by an inverse interfacial polymerization technique. More specifically, the present invention offers a method for substantially reducing the amount of low molecular weight fraction which accompanies the formation of these polyesters when prepared by standard interfacial polymerization techniques by (1) inverting the order of addition of one phase to the other, i.e. by adding the aqueous phase to the organic phase, (2) controlling the rate of addition of the aqueous phase to the organic phase and (3) adding the catalyst to the organic phase prior to the addition of the aqueous phase thereto.

Inverse interfacial polymerization for preparing certain halogenated

Self-extinguishing, non-dripping, melt processible copolyesters of reduced toxicity are provided from a mixture of diols comprising from about 25 to 60 mole percent of phenolphthalein and from about 75 to 40 mole percent of ethylene glycol and a dicarboxylic acid comprising isophthalic acid and/or terephthalic acid.

Self-extinguishing, non-dripping, phenolphthalein polyester molding

An improved process is provided for the formation of metal ion containing carbon fibers which particularly are suited for utilization in electron shielding applications. An acrylic fibrous material is formed having substantially uniformly dispersed therein a halide of a transition metal. The metal halide (e.g. a chloride) present within the fibrous material is (1) converted to an oxide, (2) the fibrous material containing the metal oxide is heated in an oxygen-containing atmosphere until thermally stabilized, and (3) the thermally stabilized fibrous material is carbonized or carbonized and graphitized at a more highly elevated temperature in an appropriate atmosphere. The resulting product comprises ions of a transition metal substantially uniformly dispersed in an amorphous carbon or graphitic carbon matrix. The halide of a transition metal may be incorporated into the acrylic precursor by co-spinning and/or padding prior to thermal stabilization. The conversion of the halide of a transition metal to an oxide prior to thermal stabilization may be conducted by contact with a base or with an oxidizing agent as described.

Growing community of inventors

West Orange, NJ, United States of America

Lowell G Saferstein