Centaur Pharmaceuticals, Inc.

Lowell David Waterbury

Yong-Kang Zhang

Kirk R Maples

Allan L Wilcox

Judith A Kelleher

Hong Xu

Kenneth W Narducy

Disclosed are furan nitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compounds are useful as analytical reagents for detecting free radicals and as therapeutics for treating a wide variety of medical dysfunctions and diseases.

Furan nitrone compounds

Certain simple chemical agents, referred to herein as nitrone related therapeutics or &ldquo;NRTs&rdquo;, when administered to a patient susceptible to neovascularization (angiogenesis), can intervene and inhibit the disease's progress. Methods for therapeutically and prophylactically inhibiting angiogenesis by administering one or more NRTs are disclosed as are pharmaceutical compositions for use in such methods of treating. NRTs useful in these compositions and therapeutic methods are also disclosed.

Inhibition of angiogenesis

Disclosed are methods for treating a patient with an acute central nervous system or cardiovascular disorder or a neurodegenerative, autoimmune or inflammatory disease using a pharmaceutical composition containing a pharmaceutically acceptable carrier and an effective amount of a furan nitrone compound.

Growing community of inventors

San Carlos, CA, United States of America

Lowell David Waterbury