Janssen Pharmaceuticals, Inc.

Louris Jakob Feitsma

Jeroen Geurtsen

Eveline Marleen Weerdenburg

Jan Grijpstra

Kellen Cristhina Fae

Polypeptides comprising a FimH lectin domain comprising an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.

FimH mutant, compositions therewith and use thereof

Polypeptides comprising a FimH lectin domain comprising at least one an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.

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Utrecht, Netherlands

Louris Jakob Feitsma