Hoffmann-La Roche Inc.

Louise H Foley

Weiya Yun

Sherrie Lynn Pietranico-Cole

Nicholas J S Huby

Peter W Dunten

Ping Wang

John Westley

Allen John Lovey

Adrian Wai-Hing Cheung

Stephen B Ferguson

Robert Edward Palermo

Lilian H Sello

The present invention is a sulfonamide substituted xanthine derivative of formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is lower alkyl, lower alkyl substituted by phenyl, or lower alkyl substituted by halogen substituted phenyl; R2 is lower alkyl or lower alkyl substituted by lower cycloalkyl; and R3 is: Compounds of formula I and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.

Sulfonamide substituted xanthine derivatives

The present invention is a 1,3,8 substituted xanthine derivative of formula I or a pharmaceutically acceptable salt thereof, wherein R, Rand Rare as defined in the specification. Compounds of formula I and pharmaceutically acceptable salts or prodrugs thereof show activity as modulators of gluconeogenesis.

Amide substituted xanthine derivatives

7-aryl-6(Z)-heptatrienoic acid retinamides

Pyrimidine-2,4,6-triones

There is presented compounds of the formula ##STR1## wherein R is C.sub.2 to C.sub.7 alkyl or lower alkyl hydroxy and their pharmaceutically acceptable salts. The compounds exhibit activity as antimalarial, anti-inflammatory, anticoccidial and animal growth promotant agents.

Ethers of antibiotic X-14868A

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Fort Myers, FL, United States of America

Louise H Foley