The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth

The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth, Near Dublin

The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth, Near Dublin

Louise Clune-Moriarty

John Francis Gilmer

Maeve Lally

Aspirin is one of the most widely used drugs in the treatment of inflammation, pain and fever. It has more recently found application in the prevention of heart attacks and stroke and is being studied as a cancer chemopreventative agent. Despite its value aspirin continues to be underutilized because it causes gastric bleeding. The technology under development potentially removes this problem. It is designed to reduce contact between the drug and the intestinal lining. An isosorbide aspirinate prodrug compound is thus provided. The compound has the general structure as shown in general formula (I) wherein Y is a C-Calkyl ester, a C-Calkoxy ester, a C-Ccycloalkyl ester, an arylester, a C-Calkylaryl ester or &#x2014;C(O)OR, wherein Ris a 5-membered aromatic or nonaromatic 5-member ring having at least one heteroatom substituted for a carbon of the ring system, which can be unsubstituted or substituted with at least one nitric oxide releasing group. 

Growing community of inventors

Quin, Ireland

Louise Clune-Moriarty