Pneuma Respiratory, Inc.

Eastman Chemical Company

Eyenovia, Inc.

Medical University of South Carolina

Amcol International Corporation

Westlake Longview Corporation

Grupo Petrotemex S.a. De C.v.

Louis Thomas Germinario

Charles Eric Hunter

John Hilbert Hebrank

Christopher W Maurer

Chengjie Li

Jack C Hunter

Shriram Bagrodia

Iyam Lynch

Jonathan Ryan Wilkerson

Tie Lan

Steven Lee Stafford

John Walker Gilmer

Vasiliki Psihogios

Joshua Richard Brown

Richard Kingsley Stuart, Jr

Eric Jon Moskala

Thomas P Stern

Michael Eugene Donelson

Ronald R Light

Kris Grube

Emerson Eston Sharpe, Jr

J Sid Clements

James Thornhill Leath

Nathan R Faulks

Jeffery Lynn Presley

Lavonna Suzanne Buehrig

Matthew Ditrolio

John H Hebrank

Max Allen Weaver

Samuel D Hilbert

Wayne P Pruett

Rodney Layne Piner

Jack Wesley Trexler, Jr

David Gayle Salyer

David Paul Fischer

Steven Matthew Scheffer

Fabian Clarke Pike

Darrin James Nicholson

Maurice Harold Hodgson

Jeff Erich Neff

Terrill M McGee

Gary Wayne Minnick

James A Wrycha

Jeffrey Lynn Presley

Lyam Lynch

Ronald Richard Light

An electronically actuated droplet delivery device includes a housing with an airflow exit at a mouthpiece and an airflow entrance in fluid communication with the airflow exit via an airflow channel. An aperture plate coupled to an electronic actuator energized by a power source produces a droplet plume from a fluid reservoir in fluid communication with the aperture plate. A change of airflow trajectory in the airflow channel and/or a fan provides inertial filtering and removal of droplets in the plume that have a mass mean aerodynamic diameter greater than 5 μm.

Droplet device with inertial filtering

A nasal droplet delivery device and related methods for delivering precise and repeatable dosages to a subject via the nasal passageways and sinus cavities.

Nasal drug delivery apparatus and methods of use

An ejector device for ejecting droplets of fluid onto a surface includes an ejector mechanism attached to a fluid reservoir through a fluid loading plate that is configured to pierce the reservoir and channel the fluid to a rear surface of the ejector mechanism by capillary action. The ejector mechanism may have a centro-symmetric configuration with a lead free piezo actuator and may be covered by an auto-closing cover.

Spray ejector device and methods of use

A droplet delivery device with a small volume drug ampoule and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device is configured to facilitate the ejection of small, e.g., single use, volumes of a therapeutic agent. The droplet delivery device includes a housing, a mouthpiece, a small volume drug ampoule, an ejector mechanism, and at least one differential pressure sensor. The delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 &#x3bc;m, so as to target the pulmonary system of the user. The small volume drug ampoule may include a reservoir which comprises an internal flexible membrane separating two internal volumes, a first background pressure fluid volume and a second drug volume.

Electronic breath actuated in-line droplet delivery device with small volume ampoule and methods of use

An in-line droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The in-line droplet delivery device includes a housing, a mouthpiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The in-line droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The in-line droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 &#x3bc;m, so as to target the pulmonary system of the user. the droplet delivery device is configured in an in-line orientation in that the housing, its internal components, and various device components (e.g., the mouthpiece, air inlet flow element, etc.) are orientated in a substantially in-line or parallel configuration (e.g., along the airflow path) so as to form a small, hand-held device.

Electronic breath actuated in-line droplet delivery device and methods of use

A dry powder aerosol delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The dry powder aerosol delivery device includes a housing, a cartridge, and a dry powder dispersion mechanism, and at least one differential pressure sensor. The dry powder delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The dry powder aerosol delivery device is then actuated to generate a plume of particles having an average ejected particle diameter within the respirable size range, e.g., less than about 5-6 &#x3bc;m, so as to target the pulmonary system of the user.

Dry powder delivery device and methods of use

A nasal droplet delivery device and related methods for delivering precise and repeatable dosages to a subject via the nasal passageways and sinus cavities is disclosed. The droplet delivery device includes a housing, a nosepiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically actuated by the user when the differential pressure sensor senses a predetermined pressure change within the nosepiece. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter of greater than about 6 microns, preferably greater than about 10 micron, so as to target the nasal passageways and sinus cavities of the user.

A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 &#x3bc;m, so as to target the pulmonary system of the user.

Methods for generating and delivering droplets to the pulmonary system using a droplet delivery device

Methods for the systemic delivery of therapeutic agents to the pulmonary system using a droplet delivery device

Methods for treatment of pulmonary lung diseases with improved therapeutic efficacy and improved dose efficiency

Systems and methods comprising a droplet delivery device and a breathing assist device for therapeutic treatment

An ejector device and method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use is disclosed. The ejector device includes a housing, a reservoir disposed within the housing for receiving a volume of fluid, and an ejector mechanism in fluid communication with the reservoir and configured to eject a stream of droplets, the ejector mechanism comprising an ejector plate coupled to a generator plate and a piezoelectric actuator; the piezoelectric actuator being operable to oscillate the ejector plate, and thereby the generator plate, at a frequency and generate a directed stream of droplets.

Ejector mechanism, ejector device, and methods of use

High modulus polymeric ejector mechanism, ejector device, and methods of use

Growing community of inventors

Kingsport, TN, United States of America

Louis Thomas Germinario