University of Washington

Universitè Laval

Tcp Reliable, Inc.

Hérma-Québec

Klaus H. Haarmann

Serghe Lapointe

Maurice Barakat

Anthony Alleva

Mario Tremblay

Annie Beausejour

Louis Thibault

Michael H Gelb

Eric Boilard

Klaus H Haarmann

Luc Boudreau

Annie Beauséjour

The present disclosure highlights the relationship between extracellular mitochondrial components, optionally in combination with the secreted phospholipase A-IIA and/or an auto-antibody, and in vivo as well as in vitro and inflammatory reactions/conditions, especially those released as a result of the degradation of a platelet. The present disclosure provides methods for determining the presence of inflammatory mediators, for limiting inflammatory reactions/conditions, for the diagnosis inflammatory reactions/conditions, for screening therapeutics for the treatment and/or the alleviation of symptoms of inflammatory reactions/conditions based on the detection or modulation of the level of these extracellular mitochondrial components.

Extracellular mitochondrial components for detecting inflammatory reactions and conditions

A new blood unit cooling system was designed to cool blood rapidly to about 22&#xb0; C. and maintain it at about that temperature, even in ambient temperature extremes, for several hours. The system incorporating a preferred eutectic solution including 98% 1-dodecanol, 1.5% myristyl alcohol and 0.5% 1-decanol (having a melting point of about 23&#xb0; C.) contained in a sealed flexible polymer layer, was used to cool whole blood-filled bags. The preferred design used double-layered transparent polyethylene, with two sealed compartments filled with the solution, separated by a flattened and sealed portion between them. One of the two sealed compartments contacts one side of the blood bag and the other compartment is folded over to contact the other side of the blood bag. The transparent compartments allows an operator to verify at any time whether the solution is in a solid state, and the flexibility of the compartments eases the proper positioning of them around a blood bag.

Rapid cooling to and maintaining of whole blood at 20 to 24C for processing

Growing community of inventors

St-Augustin-de-Desmaures, Canada

Louis Thibault