Tufts University

Other

Galenea Corp.

Louis Shuster

Nicholas H Dodman

Liang Xin Xu

Howard Paul Sard

Bryan Roth

Cynthia Morency

Govindaraj Kumaran

Novel indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds.

Indole compounds useful as serotonin selective agents

NMDA receptor antagonists can be used in methods of treatment, for reducing the frequency of stereotypic behaviors in animals and for reducing the frequency of analogous compulsive behaviors in humans, for example, those that have been said to be a manifestation of, or related to, obsessive-compulsive disorder. Of particular interest are the (&plus;) enantiomers of opioid receptor binding compounds, which can reduce the frequency of the behaviors, while having no effects from binding at the opioid receptor.

Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors

The present invention provides a veterinary treatment method for animals suffering from a high arousal state. The treatment employs a class of pharmacologically active compounds having a pyrimidinyl-piperazine ring structure of which the most preferred member is buspirone. These compounds are administered to a variety of different domestic animals and household pets exhibiting behavioral problems which often are refractory to other modes of treatment.

Veterinary method for treating inappropriate elimination of urine in

A method of treating animals exhibiting stereotypic behavior by administering a therapeutically effective amount of a narcotic antagonist is disclosed. The stereotypic behaviors include cribbing, wind-sucking, head bobbing, head skaking, head nodding, pacing, pawing and stall-walking. A kit for treating this stereotypic behavior is also disclosed.

Growing community of inventors

Brighton, MA, United States of America

Louis Shuster