University of California

Cedars-sinai Medical Center

Louis S Bouchard

Alexander Pines

Shoujun Xu

Dmitry Budker

Micah Ledbetter

Khalid Youssef

David E Wemmer

Shawn Wagner

Elad Harel

Stefan Gloeggler

Jianping Hu

Thomas Lowery

Jeffrey Paulsen

Christian Hilty

At least some embodiments of the present disclosure relate to a method of training an artificial neural network (ANN) for an artificial intelligence recognition. The method includes producing, by an ANN, outputs by feeding inputs of a training data set to the ANN; determining errors of the generated outputs from target outputs of the training data set; generating a first-order derivative matrix including first-order derivatives of the errors and a second-order derivative matrix including second-order derivatives of the errors; obtaining an approximation of the first-order derivative matrix or an approximation of the second-order derivative matrix by compressing the first-order derivative matrix or the second-order derivative matrix; and updating weights of the ANN based on the approximation of the first-order derivative matrix or the approximation of the second-order derivative matrix.

Training artificial neural networks with reduced computational complexity

A heterogeneous catalyst composition for para-hydrogen induced polarization includes ligand-capped nanoparticles dispersed in water. The ligand-capped nanoparticles include metal nanoparticles that are surface functionalized with organic ligands, a molecular weight of the organic ligands is no greater than 300 g/mol, and the organic ligands each includes multiple binding moieties as coordinates sites for binding to a nanoparticle surface.

Biologically applicable water-soluble heterogeneous catalysts for para-hydrogen induced polarization

Described herein are a magnetic resonance probe and a NMR, MRI, or EPR apparatus including the same. The magnetic resonance probe includes a conductor electrically coupled to the resonator and configured to transmit and receive electromagnetic radiation to and from a sample, wherein the conductor includes one or more cascaded narrowed regions along its longitudinal dimension and a slot within one of the one or more cascaded narrowed regions; and an electrical circuit coupled to the conductor and the resonator.

Miniaturized magnetic resonance probe

A noise removal method includes receiving in a de-noising system multiple noisy copies of a target image; providing the noisy copies as input data to the de-noising system in a training phase, and determine a noise distribution for the plurality of noisy copies. The method further includes, for n stages of the de-noising system, transforming the input data into an output; reconstructing the output; and providing the reconstructed output as input data. The method may further include receiving a new image and generating a de-noised image based on the determined noise distribution.

Feature-preserving noise removal

System and methods for designing and using single-sided magnet assemblies for magnetic resonance imaging (MRI) are disclosed. The single-sided magnet assemblies can include an array of permanent magnets disposed at selected positions. At least one of the permanent magnets can be configured to rotate about an axis of rotation in the range of at least +/&#x2212;10 degrees and can include a magnetization having a vector component perpendicular to the axis of rotation. The single-sided magnet assemblies can further include a magnet frame that is configured to hold the permanent magnets in place while allowing the at least one of the permanent magnets to rotate about the axis of rotation.

Adjustable permanent magnet assembly for NMR and MRI

A novel approach to magnetic resonance imaging is disclosed. Blood flowing through a living system is prepolarized, and then encoded. The polarization can be achieved using permanent or superconducting magnets. The polarization may be carried out upstream of the region to be encoded or at the place of encoding. In the case of an MRI of a brain, polarization of flowing blood can be effected by placing a magnet over a section of the body such as the heart upstream of the head. Alternatively, polarization and encoding can be effected at the same location. Detection occurs at a remote location, using a separate detection device such as an optical atomic magnetometer, or an inductive Faraday coil. The detector may be placed on the surface of the skin next to a blood vessel such as a jugular vein carrying blood away from the encoded region.

Magnetic resonance imaging of living systems by remote detection

A method and apparatus are described wherein a micro sample of a fluidic material may be assayed without sample contamination using NMR techniques, in combination with magnetoresistive sensors. The fluidic material to be assayed is first subject to pre-polarization, in one embodiment, by passage through a magnetic field. The magnetization of the fluidic material is then subject to an encoding process, in one embodiment an rf-induced inversion by passage through an adiabatic fast-passage module. Thereafter, the changes in magnetization are detected by a pair of solid-state magnetoresistive sensors arranged in gradiometer mode. Miniaturization is afforded by the close spacing of the various modules.

Growing community of inventors

Berkeley, CA, United States of America

Louis S Bouchard