Ramscor, Inc.

Icon Bioscience, Inc.

Louis L Wood

Vernon G Wong

Glenn T Huang

This invention provides for biocompatible, biodegradable eye drop pharmaceutical formulations useful for the treatment of ocular indications. In particular, tocopherols and their esters of low water solubility, notably &#x3b1;-tocopheryl acetate, are exceptional vehicles for biocompatible, nonirritating topical eye drop formulations that provide sustained release of active agents.

Sustained release eye drop formulations

The present invention provides for injectable pharmaceutical sustained release formulations for delivery of active agents, particularly therapeutic proteins, to the eye. The formulations are biocompatible, biodegradable sustained release formulations comprising low-solubility liquid excipients and relatively small amounts (less than about 10%) of biocompatible, biodegradable polymer such as PLA or PLGA polymers. A unit dose of 5 &#x3bc;L to 100 &#x3bc;L of the formulation provides for sustained release of the agent for at least 14 days.

Sustained release formulations for delivery of proteins to the eye and methods of preparing same

The present invention provides for compositions, medicaments, and methods for treating or alleviating the symptoms of dry eye syndrome or chronic dry eye. More specifically, the present embodiments provide for medicaments consisting of tocopherol or tocotrienol eyedrops. A single topical administration of tocopherol or tocotrienol eyedrops in the eyes of a subject suffering from dry eye alleviates symptoms for at least one day. In particular, the eyedrop medicament consists of &#x3b1;-tocopheryl acetate; &#x3b1;-tocopheryl acetate and about 0.5% aqueous component; or &#x3b1;-tocopheryl acetate, about 2.5% tocopherol emulsifier, and about 20% to about 30% aqueous excipient.

Composition and method for treating dry eye syndrome

The present embodiments provide for sustained release formulations of antioxidants that are useful in treating afflictions of the eye and tumors.

Conveniently injectable or implantable sustained-release antioxidant formulations for therapies of ocular maladies or cancer

This invention provides for biocompatible and biodegradable syringeable liquid, implantable solid, and injectable gel pharmaceutical formulations useful for the treatment of systemic and local disease states.

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Potomac, MD, United States of America

Louis L Wood