Laboratoire L. Lafon

Societe Anonyme Dite: Laboratoire L. Lafon

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Laboratoire L. Lafton

Louis L Lafon

Victor Lafon

Brynjulf Ottar

Louis Rey

The invention relates to [.alpha.-(tert.butyl aminomethyl)-3,4-dichlorobenzyl] thioacetamide of the formula: ##STR1## and its addition salts with pharmaceutically acceptable acids. These compounds can be used as antidepressants as well as to promote the feed intake.

[.alpha.-tert.butyl aminomethyl)-3,4-dichlorobenzyl] thioacetamide, a

The present invention relates to compounds of formula: ##STR1## in which A is selected from pyrrolidino, piperidino, morpholino, 1-imidazolyl, hexamethylenimino and 1-piperazinyl groups, these groups being unsubstituted or it being possible for them to contain 1 or 2 substituents selected from C.sub.1 -C.sub.3 alkyl and C.sub.1 -C.sub.3 hydroxyalkyl groups, and the addition salts of these compounds with pharmaceutically acceptable acids. These compounds are usable in therapy as peripheral vasodilators.

Aminoalkyl thienyl ketone derivatives and their use as peripheral

The invention relates to compounds having the formula: ##STR1## in which Ar represents a group selected from 2-nitrophenyl, 3-nitrophenyl, 2-chlorophenyl, 2,6-dichlorophenyl, 2-trifluoromethylphenyl and 3-trifluoromethylphenyl;

Derivatives of 1,4-dihydropyridine, their preparation procedure and

The present invention relates to the preparation of new 1-(aminophenyl)-2-aminopropanone derivatives of the general formula: ##STR1## in which X is NH.sub.2, Y is H or a halogen atom, Z is H or a halogen atom, R.sub.1 is C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.6 cycloalkyl and R.sub.2 is H or C.sub.1 -C.sub.4 alkyl, or R.sub.1 and R.sub.2, taken together, can form, with the nitrogen atom to which they are bonded, a heterocyclic group selected from the group consisting of the pyrrolidino, morpholino, thiomorpholino, piperidino, hexamethyleneimino, piperazino, 4-methyl-piperazino, 4-(.beta.-hydroxyethyl)piperazino, 4-phenyl-piperazino and 4-(p-chlorophenyl)piperazino groups, and addition salts thereof. These new derivatives are useful as pharmaceuticals. They are obtained by deacetylation of the corresponding acetylated products.

Method for treating depression using 1-(aminophenyl)-2-aminopropanone

The present invention relates to a method for providing a patient with neuroprotective effect, which consists in administering modafinil to said patient.

Method for providing a neuroprotective effect

The present invention relates to 1-(4-aminophenyl)-2-piperidinopropanone derivatives which are selected from

1-(4-aminophenyl)-2-piperidinopropanone derivatives, preparation process

The present invention relates to 1-(4-aminophenyl-2)-hexamethyleniminopropanone and its pharmaceutically acceptable addition salts. These products are useful in therapy on account of their antidepressant effects on the CNS and their immunological properties.

1-(4-aminophenyl)-2-hexamethyleniminopropanone, and their use in therapy

The present invention relates to the preparation of new 1-(aminophenyl)-2-aminopropanone derivatives of the general formula: ##STR1## in which X is NH.sub.2, Y is H or a halogen atom, Z is H or a halogen atom, R.sub.1 is C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.6 cycloalkyl and R.sub.2 is H or C.sub.1 -C.sub.4 alkyl, or R.sub.1 and R.sub.2, taken together, can form, with the nitrogen atom to which they are bonded, a heterocyclic group selected from the group consisting of the pyrrolidino, morpholino, thiomorpholino, piperidino, hexamethyleneimino, piperazino, 4-methyl-piperazino, 4-(.beta.-hydroxyethyl)piperzaino, 4-phenylpiperazino and 4-(p-chlorophenyl)piperazino groups, and addition salts thereof. These new derivatives are useful as pharmaceuticals. They are obtained by deacetylation of the corresponding acetylated products.

1-(aminophenyl)-2-aminopropanone derivatives

The present invention relates, by way of new industrial products, to 1-(acetylaminophenyl)-2-amino-propanone derivatives selected from the group consisting of

1-(acetylaminophenyl)-2-aminopropanone derivatives and pharmaceutical

1-(acetylaminophenyl)-2-aminopropanone derivatives and central nervous

The present invention relates, by way of novel industrial products, to 1-(4-aminophenyl)-2-dimethylaminopropanone derivatives which are selected from:

1-aminophenyl-2-dimethylaminopropanone derivatives, method of

The levorotatory isomer of benzhydrylsulfinylacetamide has useful pharmaceutical activity on the central nervous system, particularly as an antidepressant and stimulant in the treatment of hypersomnia and Alzheimer's disease.

Levorotatory isomer of benzhydrylsulfinyl derivatives

The present invention relates, by way of new industrial products, to phenylpiperazine derivatives selected from the group comprising 3-methyl-2-phenylpiperazine, 1-isopropyl-3-phenylpiperazine, 1-ethyl-2-methyl-3-phenylpiperazine, 1-isopropyl-2-methyl-3-phenylpiperazine, 1,2,4-trimethyl-3-phenylpiperazine, and (halogenophenyl)alkyl-piperazines of the formula: ##STR1## (wherein X.sub.o is F, Cl or Br, R.sub.1 is H or C.sub.1 -C.sub.4 alkyl, R.sub.2 is H or C.sub.1 -C.sub.2 alkyl and R.sub.3 is H or C.sub.1 -C.sub.4 alkyl, at least one of the symbols R.sub.1, R.sub.2 and R.sub.3 being different from H), and addition salts thereof. These new products are useful as antidepressants for the CNS.

Antidepressive substituted phenylpiperazine compounds

The present invention relates, by way of a novel industrial product, to a filter for gaseous fluid, which contains a lyophilized and compressed filter element in the form of a porous layer.

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Paris, France

Louis L Lafon