Collagen Corporation

Matrix Pharmaceutical, Inc.

Louis Fries

Frank A DeLustro

Woonza M Rhee

Donald G Wallace

Hanne Bentz

Ramon A Burns, Jr

Alan S Michaels

Daniel R Prows

Richard Lee

Thomas L Smestad

Ann B Brannan

Roseann Burhenne

Rees M Orland

Kimberly McCullough

Ramesh Damani

An apparatus is provided having a rotor inside a membrane for the aseptic vortex flow concentration of a liquid or semisolid dispersion which has a shed-resistant bearing interface so that unwanted bearing material does not contaminate the substances, e.g., pharmaceutical and biological materials, that are being processed.

Apparatus for aseptic vortex flow concentration

A process for the aseptic concentration of collagen from about 0.25% (w/w) suspensions to gels of 15% using vortex flow filtration with a variety of membrane types--ultrafiltration and microfiltration and polymeric and stainless steel is provided. The resulting gels are suitable for use in medical products and/or pharmaceutical formulations. This process achieves high degree of concentration in a closed system and at high flux with minimal trans-membrane pressure drop.

Aseptic collagen concentration process

Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type I, type II or type III and may be fibrillar or non-fibrillar. The synthetic hydrophilic polymer may be polyethylene glycol and derivatives thereof having a weight average molecular weight over a range of from about 100 to about 20,000. The compositions may include other components such as liquid, pharmaceutically acceptable, carriers to form injectable formulations, and/or biologically active proteins such as growth factors. The collagen-polymer conjugates of the invention generally contain large amounts of water when formed. The conjugates can be dehydrated to form a relatively solid object. The dehydrated, solid object can be ground into particles which can be suspended in a non-aqueous fluid such as an oil and injected into a living being for the purpose of providing soft tissue augmentation. Once in place, the particles rehydrate and expand in size five fold or more.

Polymer conjugates ophthalmic devices comprising collagen-polymer

Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.

Implants coated with collagen-polymer conjugates

Method of preparing collagen-polymer conjugates

Collagen-polymer conjugates containing an ether linkage

Collagen-polymer conjugates

A device for correcting fine superficial facial lines which comprises a syringe fitted with a 31-33 gauge needle and an aqueous suspension of noncrosslinked fibrillar atelopeptide collagen contained within the syringe barrel, the concentration of collagen in the suspension being in the range of 10 to 50 mg/ml and the suspension exhibiting an extrusion plot in which there is a smooth substantially linear increase in force up to a substantially constant force in the range of 5 to 30 newtons.

Method for treating fine superficial facial lines

Method of augmenting tissue using collagen-polymer conjugates

Device for treating fine superficial facial lines

Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding biologically inactive, natural, biocompatible polymer to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide biocompatible conjugates. The synthetic hydrophilic polymer may be polyethylene glycol and derivatives thereof having a weight average molecular weight over a range of from about 100 to about 20,000. The compositions may include other components such as liquid, pharmaceutically acceptable, carriers to form injectable formulations, and/or biologically active proteins such as growth factors. The conjugates of the invention generally contain large amounts of water when formed. The conjugates can be dehydrated to form a relatively solid object. The dehydrated, solid object can be ground into particles which can be suspended in a non-aqueous fluid such as an oil and injected into a living (preferably human) being for the purpose of providing soft tissue augmentation. Once in place, the particles rehydrate and expand in size five fold or more.

Biologically inert, biocompatible-polymer conjugates

Medical articles in the form of strings are formed by covalently binding collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugate formulations which are extruded to make the strings. The collagen may be recombinantly produced human collagen or collagen extracted from any source, such as a bovine source or human placenta, and purified and can be of various types and may be fibrillar or non-fibrillar. The synthetic hydrophilic polymer may be polyethylene glycol and derivatives thereof having an average molecular weight over a range of from about 100 to about 20,000. The string can be designed to incorporate other components such as fluid, pharmaceutically acceptable carriers to form injectable formulations, and/or biologically active proteins such as growth factors or cytokines. The strings contain large amounts of water when extruded and may then be dehydrated to form relatively solid but flexible strings. The strings can be injected into a living being for the purpose of providing soft tissue augmentation. Once in place, the strings rehydrate and expand in size five fold or more. Aqueous solution can be provided to enhance the rate of rehydration. The strings can also be used to suture wounds which strings can be chemically designed to dissolve in situ.

Dehydrated collagen-polymer strings

Method of augmenting tissue with collagen-polymer conjugates

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Los Altos, CA, United States of America

Louis Fries