Massachusetts Institute of Technology

Institut National De La Sante Et De La Recherche Medicale

Louis Dubertret

Eugene Bell

Emile R Bisagni

Dietrich Averbeck

Francois Zajdela

Silvano Nocentini

Paul Vigny

Maria N Schwencke

Jocelyne Blais

Ethel Moustacchi

Dora Papadopoulo

Jacqueline Moron

An improvement in the preparation of living skin-equivalents from contracted hydrated collagen lattices having keratinocyte cells on the surface is disclosed herein. In this improvement, punch biopsies of skin are employed to provide a source of keratinocyte cells to the lattices.

Skin-equivalent prepared by the use of punch biopsy

Monofunctional psoralen derivatives having the general formula ##STR1## wherein R represents a hydrogen atom, a lower alkyl group having from 1 to 4 atoms, preferably a methyl radical, or a lower alkoxy radical having from 1 to 4 carbon atoms, preferably a methoxy radical are described. The derivatives are photobiologically active and are useful in photochemical therapy and in cosmetics.

(3,4-c)-Pyrido psoralens, process of preparation, application in

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Paris, France

Louis Dubertret