Merck + Co., Inc.

Louis Chaiet

Sheldon B Zimmerman

Richard L Monaghan

George M Garrity

Yoshiharu Morita

Sebastian Hernandez

Maria I Fernandez

Junko Takashima

Ryoichi Ando

Maria I Martin

New peptide derivatives .beta.-chloro-L-(Z)-dehydroglutamic acid are described which display antibacterial activity.

Peptide derivatives of .beta.-chloro-L(Z)-dehydro-glutamic acid

A new antifungal agent which exhibits a moderately broad spectrum of activity towards filamentous fungi and also against Cryptococcus species of the yeast fungi, and which has been isolated from a solid stationary fermentation of an unidentified species of Fusarium is described.

Antifungal fermentation product

R-(Z)-4-amino-3-chloro-2-pentenedioic acid is a novel antibacterial and isolated from Streptomyces viridogenes MA5450, ATCC 39387.

R-(Z)-4-amino-3-chloro-2-pentenedioic acid, novel antibacterial agent

This case relates to a novel process for aiding in the isolation and purification of novel compounds which are produced by the microorganism, Streptomyces avermitilis. The process described herein utilizes a bed of activated alumina and a bed of activated carbon, respectively. The compounds which are isolated and purified are described generically as C-076 and have significant parasiticidal activity.

Purification of C-076 compounds by single column chromatography

This invention relates to a novel process for the preparation of the antibiotic Sulfomycin. The antibiotic is obtained by the fermentation of a nutrient medium with a Sulfomycin producing strain of the previously unknown microorganism Streptomyces cineroviridis.

Growing community of inventors

Springfield, NJ, United States of America

Louis Chaiet