Baylor College of Medicine

Genetronics Biomedical Corporation

Vgx Pharmaceuticals, Inc.

Inovio Pharmaceuticals, Inc.

Genetronics, Inc.

Louis C Smith

Richard J Cristiano

Jim Sparrow

Stephen Gottchalk

Savio L Woo

Alain Rolland

Jason Fewell

Fiona MacLaughlin

Francois Nicol

Ruxandra Draghia-Akli

Robert Hunt Carpenter

Amir S Khan

James T Sparrow

Savio L C Woo

Jeff Darnell

Jochen Hauer

Martha P Mims

Jason G Fewell

An electroporation device which may be used to effectively facilitate the introduction of a macromolecule into cells of a selected tissue in a body or plant. The electroporation device comprises an electro-kinetic device ('EKD') whose operation is specified by software or firmware. The EKD produces a series of programmable constant-current pulse patterns between electrodes in an array based on user control and input of the pulse parameters and allows the storage and acquisition of current waveform data. The electroporation device also comprises a replaceable electrode disk having an array of needle electrodes, a central injection channel for an injection needle, and a removable guide disk.

Constant current electroporation device and methods of use

A nucleic acid formulation for use in gene delivery comprising a nucleic acid and an anionic polymer is disclosed. Examples of the anionic polymer includes anionic amino acid polymer or poly-amino acid (such as poly-L-glutamic acid, poly-D-glutamic acid, poly-L-aspartic acid, poly-D-aspartic acid), poly-acrylic acid, polynucleotides, poly galacturonic acid, and poly vinyl sulfate.

Nucleic acid formulations for gene delivery and methods of use

A nucleic acid formulation for use in gene delivery comprising a nucleic acid and an anionic polymer is disclosed. Examples of the anionic polymer includes aniionic amino acid polymer or poly-amino acid (such as poly-L-glutamic acid, poly-D-glutamic acid, poly-L-aspartic acid, poly-D-aspartic acid), poly-acrylic acid, polynucleotides, poly galacturonic acid, and poly vinyl sulfate.

Peptide-macromolecule complexes for delivery of nucleic acid to a cell. The nucleic acid carrier includes a binding complex. The binding complex contains a binding moiety which noncovalently binds to the nucleic acid. The binding complex can also contain a binding moiety which is associated with a surface ligand, nuclear ligand or a lysis agent. These may be associated with the binding moiety by spacers. In addition, the carrier may include a nucleic acid with a combination of the above binding complexes or binding moieties.

Lipophilic peptides for macromolecule delivery

Nucleic acid transporter systems for delivery of nucleic acid to a cell. The nucleic acid transporter includes a binding complex. The binding complex contains a binding molecule which non-covalently binds to the nucleic acid and covalently links to a surface ligand, nuclear ligand and/or a lysis agent. These may be linked to the binding molecule by spacers.

Nucleic acid transporter systems

Nucleic acid transporter systems and methods of use

Nucleic acid transporter system and methods of use

Growing community of inventors

Houston, TX, United States of America

Louis C Smith