Georgia Tech Research Corporation

North Carolina State University

University of Virginia Patent Foundation

Louis Andrew Lyon

Ashley Carson Brown

Robert Martin Dickson

Thomas Harrison Barker

Nicole Welsch

Sarah E Stabenfeldt

John Francis McDonald

John Nicosia

Erin Beth Dickerson

Thomas H Barker

William Hobart Blackburn

Ultra-low crosslinked microgels made of an ultra-low crosslinked polymer are provided. The microgels, also referred to as Platelet-like Particles (PLPs), preferably have &#x3c;0.5% crosslinking densities. One or more of the polymers are conjugated with a fibrin-binding element or moiety, preferably H6, in an amount effective to confer to the microgel selective binding to fibrin under physiological conditions. The PLPs can recapitulate multiple key functions of platelets including binding, stabilizing and enhancing fibrin clot formation, responsiveness to injury cues, and induction of clot contraction. In a preferred embodiment, the microgel or PLP has little or no binding to soluble fibrinogen under physiological conditions compared to its binding to fibrin. The microgels or PLPs are prepared using crosslinker-free synthesis conditions, and can promote or induce clotting and clot contraction.

Functionalized microgels with fibrin binding elements

The various embodiments of the present disclosure relate generally to nanogels for the cellular delivery of therapeutics and methods of using the same. More particularly, the various embodiments of the present invention are directed to systems and methods for the targeted treatment of neoplastic using nanogel-based technologies. In an embodiment of the present invention, a nanogel-based delivery system comprises: a nanogel comprising a crosslinked polymer particle; and an active agent contained substantially within the nanogel, wherein the active agent is non-covalently associated with the nanogel.

Nanogels for cellular delivery of therapeutics

An apparatus and method are provided for converting light into a surface plasmon polariton on a plasmon supporting nanostructure and then controlling the emission of the re-emitting light. A circuit component is also described that is constructed of a nanostructure, which is comprised of at least one plasmon supporting metal. The metal can propagate the light, as a surface plasmon polariton, through the one-dimensional nanostructure and re-emit the light. The metal is a plasmon supporting metal, for example but not limited to, gold, silver, copper, and aluminum.

Apparatus and method of optical transfer and control in plasmon supporting metal nanostructures

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Louis Andrew Lyon