University of California

Los Alamos National Security, LLC

Medical University of South Carolina

The Proctor 'gamble Company

Louis A Silks

Clifford J Unkefer

Rodolfo Antonio Martinez

Jurgen G Schmidt

John Cameron Gordon

Marc A Alvarez

Ruilian Wu

Basil I Swanson

Andrew D Sutton

Susan Kloek Hanson

Xuedong Song

Jin Kyung Kim

David Bryan Kimball

Rashi Iyer

Kumkum Ganguly

Ruilan Wu

Dimitris Ioannis Collias

Ryan Michael West

Ryszard Michalczyk

R Bruce Dunlap

Jerome D Odom

Robert Atcher

Marcel Schlaf

Fraser Waldie

Embodiments of the present invention are directed to the conversion of a source material (e.g., a depolymerized oligosaccharide mixture, a monomeric sugar, a hydrolysate, or a mixture of monomeric sugars) to intermediate molecules containing 7 to 26 contiguous carbon atoms. These intermediates may also be converted to saturated hydrocarbons. Such saturated hydrocarbons are useful as, for example, fuels.

Conversion of oligomeric starch, cellulose, hydrolysates or sugars to hydrocarbons

The present invention is directed to the one step selective conversion of starch, cellulose, or glucose to molecules containing 7 to 26 contiguous carbon atoms. The invention is also directed to the conversion of those intermediates to saturated hydrocarbons. Such saturated hydrocarbons are useful as, for example, fuels.

Conversion of oligomeric starch, cellulose, or sugars to hydrocarbons

The present invention is directed to the preparation of oxygenated, unsaturated hydrocarbon compounds, such as derivatives of furfural or hydroxymethyl furfural produced by aldol condensation with a ketone or a ketoester, as well as methods of deoxidatively reducing those compounds with hydrogen under acidic conditions to provide saturated hydrocarbons useful as fuels.

Compounds and methods for the production of long chain hydrocarbons from biological sources

The invention concerns processes for oxidizing an alcohol to produce a carbonyl compound. The processes comprise contacting the alcohol with (i) a gaseous mixture comprising oxygen; and (ii) an amine compound in the presence of a catalyst, having the formula: where each of R-Rare independently H, alkyl, aryl, CF, halogen, OR, SOR, C(O)R, CONRRor COR; each of R-Ris independently alkyl or aryl; and Z is alkl or aryl.

Mild and selective vanadium-catalyzed oxidation of benzylic, allylic, and propargylic alcohols using air

Method of producing C-Chydrocarbons comprising providing a ketone starting material; providing an aldol starting material comprising hydroxymethylfurfural; mixing the ketone starting material and the aldol starting material in a reaction in the presence of a proline-containing catalyst selected from the group consisting of Zn(Pro), Yb(Pro), and combinations thereof, or a catalyst having one of the structures (I), (II) or (III), and in the presence of a solvent, wherein the solvent comprises water and is substantially free of organic solvents, where (I), (II) and (III) respectively are:  In (III), X may be CH, sulfur or selenium, M may be Zn, Mg, or a lanthanide, and Rand Reach independently may be a methyl, ethyl, phenyl moiety.

Method of carbon chain extension using novel aldol reaction

Method of producing C-Chydrocarbons. comprising providing a ketone starting material; providing an aldol starting material comprising chloromethylfurfural; mixing the ketone starting material and the aldol starting material in a reaction in the presence of a proline-containing catalyst selected from the group consisting of Zn(Pro), Yb(Pro), and combinations thereof, or a catalyst having one of the structures (I), (II) or (III), and in the presence of a solvent, wherein the solvent comprises water and is substantially free of organic solvents, where (I), (II) and (III) respectively are:   In (III), X may be CH, sulfur or selenium, M may be Zn, Mg, or a lanthanide, and Rand Reach independently may be a methyl, ethyl, phenyl moiety.

Bacterial quorum-sensing molecule analogs having the following structures: and methods of reducing bacterial pathogenicity, comprising providing a biological system comprising pathogenic bacteria which produce natural quorum-sensing molecule; providing a synthetic bacterial quorum-sensing molecule having the above structures and introducing the synthetic quorum-sensing molecule into the biological system comprising pathogenic bacteria. Further is provided a method of targeted delivery of an antibiotic, comprising providing a synthetic quorum-sensing molecule; chemically linking the synthetic quorum-sensing molecule to an antibiotic to produce a quorum-sensing molecule-antibiotic conjugate; and introducing the conjugate into a biological system comprising pathogenic bacteria susceptible to the antibiotic.

Synthetic analogs of bacterial quorum sensors

A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also disclosed is a trifunctional composition of matter including a trifunctional linker moiety with groups bonded thereto including (a) an alkyl chain adapted for attachment to a substrate, (b) a fluorescent moiety capable of generating a fluorescent signal, and (c) a recognition moiety having a spacer group of a defined length thereon, the recognition moiety capable of binding with tetrameric multivalent neuraminidase.

Influenza sensor

A novel nucleoside analog is disclosed which comprises a piperazine ring in the place of the ring ribose or deoxyribose sugar. Monomers utilizing a broad variety of nucleobases are disclosed, as well as oligomers comprising the monomers disclosed herein linked by a variety of linkages, including amide, phosphonamide, and sulfonamide linkages. A method of synthesizing the nucleoside analogs is also disclosed.

Piperazine-based nucleic acid analogs

Synthesis of &lsqb;2H1, 13C&rsqb;, &lsqb;2H2, 13C&rsqb; and &lsqb;2H3, 13C&rsqb;methyl aryl sulfones and sulfoxides

The present invention is directed to labeled compounds, &lsqb;2- C&rsqb;dithane wherein the C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to processes of preparing &lsqb;2- C&rsqb;dithane wherein the C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to labeled compounds, e.g., &lsqb; H , C&rsqb;methanol (arylthio)-, acetates wherein the C atom is directly bonded to exactly one or two deuterium atoms.

Synthesis of 2H- and 13C- substituted compounds

Synthesis of &lsqb;2H1, 13C&rsqb;, &lsqb;2H2, 13C&rsqb; and &lsqb;2H3, 13C&rsqb;methyl aryl sulfides

Synthesis of labeled metabolites

Growing community of inventors

Los Alamos, NM, United States of America

Louis A Silks