Pacira Pharmaceuticals, Inc.

Louie Daniel Garcia

Soroush M Ardekani

Stephanie M Kurz

Kathleen D A Los

John J Grigsby, Jr

Paige N Davis

Liangjin Zhu

Jeffrey S Hall

David J Turnbull

William Joseph Lambert

Gary Patou

Ernest George Schutt

Eran Levy

Vladimir Kharitonov

Katherine Stone

Lois Gibson

Benjamin W Li

Kathleen Dunne Albright Los

Damon A Leon

Alisha R Simonian

William F Lambert

Benjamin Li

Some embodiments of the present application are related to multivesicular liposome formulations comprising high concentration of bupivacaine for the purpose of preventing, treating or ameliorating pain, for example, post-surgical pain for an extended period of time. Processes of making and administering bupivacaine encapsulated multivesicular liposome formulations (BUP-MVLs) and their uses as medicaments are also provided.

Bupivacaine multivesicular liposome formulations and uses thereof

Some embodiments of the present application are related to multivesicular liposome (MVL) formulations encapsulating dexamethasone or an ester or an ester salt thereof, for example, dexamethasone sodium phosphate (DSP) that may provide about 3-28 days extended release of dexamethasone. Processes of making and administering dexamethasone encapsulated multivesicular liposome formulations and their uses for treating pain or inflammation are also provided.

Multivesicular liposome formulations of dexamethasone

Embodiments of the present application relate to commercial manufacturing processes for making bupivacaine multivesicular liposomes (MVLs) using independently operating dual tangential flow filtration modules.

Manufacturing of bupivacaine multivesicular liposomes

Embodiments of the present disclosure are related to multivesicular liposome formulations encapsulating zinc meloxicam complex microparticles. Methods of making the zinc meloxicam complex microparticles and administering the zinc meloxicam complex microparticles encapsulated in multivesicular liposome formulations and their use as medicaments are also provided.

Zinc meloxicam complex microparticle multivesicular liposome formulations and processes for making the same

Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.

Sustained release formulation of a non-steroidal anti-inflammatory drug

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San Diego, CA, United States of America

Louie Daniel Garcia